MRPS22 Antibody (PACO06656)
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주문- SKU:
- PACO06656
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MRPS22 Antibody (PACO06656) |
Antibody SKU: | PACO06656 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:40000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
Species Reactivity: | Human, Monkey |
Immunogen: | Synthesized peptide derived from the Internal region of human MRP-S22. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of mouse-brain 293T lysis using MRP-S22 antibody. | |
Western Blot analysis of COS7 cells using MRP-S22 Polyclonal Antibody. |
Synonyms: | MRPS22; C3orf5; RPMS22; GK002; 28S ribosomal protein S22; mitochondrial; MRP-S22; S22mt |
UniProt Protein Function: | MRPS22: Defects in MRPS22 are the cause of combined oxidative phosphorylation deficiency type 5 (COXPD5). COXPD5 is an antenatal mitochondrial disease. Patients show edema, cardiomyopathy, tubulopathy, and hypotonia. |
UniProt Protein Details: | Protein type:Mitochondrial; Ribosomal; Translation Chromosomal Location of Human Ortholog: 3q23 Cellular Component: mitochondrial inner membrane; mitochondrial ribosome; mitochondrial small ribosomal subunit; mitochondrion Molecular Function:structural constituent of ribosome Biological Process: mitochondrial translation; organelle organization and biogenesis Disease: Combined Oxidative Phosphorylation Deficiency 5 |
NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq. [provided by RefSeq, Jul 2008] |
UniProt Code: | P82650 |
NCBI GenInfo Identifier: | 13633893 |
NCBI Gene ID: | 56945 |
NCBI Accession: | P82650.1 |
UniProt Secondary Accession: | P82650,Q9H3I1, |
UniProt Related Accession: | P82650 |
Molecular Weight: | 18,972 Da |
NCBI Full Name: | 28S ribosomal protein S22, mitochondrial |
NCBI Synonym Full Names: | mitochondrial ribosomal protein S22 |
NCBI Official Symbol: | MRPS22 |
NCBI Official Synonym Symbols: | GIBT; GK002; C3orf5; COXPD5; RPMS22; MRP-S22 |
NCBI Protein Information: | 28S ribosomal protein S22, mitochondrial |
UniProt Protein Name: | 28S ribosomal protein S22, mitochondrial |
Protein Family: | 28S ribosomal protein |
UniProt Gene Name: | MRPS22 |
UniProt Entry Name: | RT22_HUMAN |