MRPS16 Antibody (PACO23351)
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주문- SKU:
- PACO23351
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MRPS16 Antibody (PACO23351) |
Antibody SKU: | PACO23351 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from internal of human MRPS16. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from HepG2 cells, using MRPS16 antibody. | |
Immunohistochemistry analysis of paraffin-embedded human tonsil tissue using MRPS16 antibody. |
Background: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described. |
Synonyms: | mitochondrial ribosomal protein S16; MRP-S16; RPMS16; RT16; S16mt |
UniProt Protein Function: | MRPS16: Defects in MRPS16 are the cause of combined oxidative phosphorylation deficiency type 2 (COXPD2). Defects in the mitochondrial oxidative phosphorylation system result in devastating, mainly multisystem, diseases. COXPD2 symptoms include fatal neonatal metabolic acidosis with agenesis of the corpus callosum. Belongs to the ribosomal protein S16P family. |
UniProt Protein Details: | Protein type:Mitochondrial; Ribosomal; Translation Chromosomal Location of Human Ortholog: 10q22.1 Cellular Component: mitochondrion; mitochondrial small ribosomal subunit; cytoplasm; mitochondrial inner membrane Molecular Function:protein binding; structural constituent of ribosome Biological Process: translation; mitochondrial translation; organelle organization and biogenesis Disease: Combined Oxidative Phosphorylation Deficiency 2 |
NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y3D3 |
NCBI GenInfo Identifier: | 7705626 |
NCBI Gene ID: | 51021 |
NCBI Accession: | NP_057149.1 |
UniProt Secondary Accession: | Q9Y3D3,Q96Q60, B4E032, |
UniProt Related Accession: | Q9Y3D3 |
Molecular Weight: | 13,829 Da |
NCBI Full Name: | 28S ribosomal protein S16, mitochondrial |
NCBI Synonym Full Names: | mitochondrial ribosomal protein S16 |
NCBI Official Symbol: | MRPS16 |
NCBI Official Synonym Symbols: | COXPD2; RPMS16; CGI-132; MRP-S16 |
NCBI Protein Information: | 28S ribosomal protein S16, mitochondrial |
UniProt Protein Name: | 28S ribosomal protein S16, mitochondrial |
Protein Family: | 28S ribosomal protein |
UniProt Gene Name: | MRPS16 |
UniProt Entry Name: | RT16_HUMAN |