MRPL18 Antibody (PACO40390)
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주문- SKU:
- PACO40390
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MRPL18 Antibody (PACO40390) |
Antibody SKU: | PACO40390 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human 39S ribosomal protein L18, mitochondrial protein (14-180AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: MRPL18 antibody at 8µg/ml. Lane 1: U251 whole cell lysate. Lane 2: THP-1 whole cell lysate. Lane 3: PC-3 whole cell lysate. Lane 4: U87 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 21 kDa. Observed band size: 21 kDa. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO40390 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO40390 at dilution of 1:100. |
Background: | Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the γ domain of the 5S rRNA. |
Synonyms: | 39S ribosomal protein L18, mitochondrial (L18mt) (MRP-L18) (Mitochondrial large ribosomal subunit protein uL18m), MRPL18 |
UniProt Protein Function: | MRPL18: Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA. Belongs to the ribosomal protein L18P family. |
UniProt Protein Details: | Protein type:Mitochondrial; Ribosomal; Translation Chromosomal Location of Human Ortholog: 6q25.3 Cellular Component: extracellular space; mitochondrial inner membrane; mitochondrial ribosome; mitochondrion Molecular Function:5S rRNA binding; structural constituent of ribosome Biological Process: mitochondrial translation; organelle organization and biogenesis; translation |
NCBI Summary: | This nuclear gene encodes a protein component of the larger 39S subunit of mitochondrial ribosome. This protein may also aid in the import of nuclear-encoded 5S rRNA into mitochondria. Alternative splicing results in multiple transcript variants, most of which are not predicted to encode a protein. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Jan 2016] |
UniProt Code: | Q9H0U6 |
NCBI GenInfo Identifier: | 41017797 |
NCBI Gene ID: | 29074 |
NCBI Accession: | Q9H0U6.1 |
UniProt Secondary Accession: | Q9H0U6,Q5TAP9, Q9NZW8, |
UniProt Related Accession: | Q9H0U6 |
Molecular Weight: | 20,577 Da |
NCBI Full Name: | 39S ribosomal protein L18, mitochondrial |
NCBI Synonym Full Names: | mitochondrial ribosomal protein L18 |
NCBI Official Symbol: | MRPL18 |
NCBI Official Synonym Symbols: | L18mt; HSPC071; MRP-L18 |
NCBI Protein Information: | 39S ribosomal protein L18, mitochondrial |
UniProt Protein Name: | 39S ribosomal protein L18, mitochondrial |
UniProt Gene Name: | MRPL18 |
UniProt Entry Name: | RM18_HUMAN |