MRC2 Antibody (PACO00760)
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주문- SKU:
- PACO00760
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MRC2 Antibody |
Antibody SKU: | PACO00760 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the N-terminal region of human Endo180. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | MRC2; CLEC13E; ENDO180; KIAA0709; UPARAP; C-type mannose receptor 2; C-type lectin domain family 13 member E; Endocytic receptor 180; Macrophage mannose receptor 2; Urokinase-type plasminogen activator receptor-associated protein; UPAR-asso |
UniProt Protein Function: | MRC2: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs). |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 17q23.2 Cellular Component: focal adhesion; membrane Molecular Function:collagen binding; protein binding Biological Process: collagen catabolic process; osteoblast differentiation |
NCBI Summary: | This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q9UBG0 |
NCBI GenInfo Identifier: | 317373394 |
NCBI Gene ID: | 9902 |
NCBI Accession: | Q9UBG0.2 |
UniProt Secondary Accession: | Q9UBG0,Q7LGE7, Q9Y5P9, A6H8K4, D3DU08, |
UniProt Related Accession: | Q9UBG0 |
Molecular Weight: | 166,674 Da |
NCBI Full Name: | C-type mannose receptor 2 |
NCBI Synonym Full Names: | mannose receptor C type 2 |
NCBI Official Symbol: | MRC2 |
NCBI Official Synonym Symbols: | CD280; UPARAP; CLEC13E; ENDO180 |
NCBI Protein Information: | C-type mannose receptor 2 |
UniProt Protein Name: | C-type mannose receptor 2 |
UniProt Synonym Protein Names: | C-type lectin domain family 13 member E; Endocytic receptor 180; Macrophage mannose receptor 2; Urokinase-type plasminogen activator receptor-associated protein; UPAR-associated protein; Urokinase receptor-associated protein; CD_antigen: CD280 |
Protein Family: | C-type mannose receptor |
UniProt Gene Name: | MRC2 |
UniProt Entry Name: | MRC2_HUMAN |