MR1 Antibody (PACO46986)
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주문- SKU:
- PACO46986
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MR1 Antibody (PACO46986) |
Antibody SKU: | PACO46986 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Major histocompatibility complex class I-related gene protein (150-253AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: MR1 antibody at 6µg/ml + K562 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 40, 35, 29, 26 kDa. Observed band size: 40 kDa.. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO46986 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO46986 at dilution of 1:100. |
Background: | Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor α chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent. |
Synonyms: | Major histocompatibility complex class I-related gene protein (MHC class I-related gene protein) (Class I histocompatibility antigen-like protein), MR1 |
UniProt Protein Function: | MR1: Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand- dependent. Belongs to the MHC class I family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1q25.3 Cellular Component: endoplasmic reticulum; plasma membrane Molecular Function:antigen binding; MHC class I receptor activity; protein binding Biological Process: antigen processing and presentation; immune response |
NCBI Summary: | MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015] |
UniProt Code: | Q95460 |
NCBI GenInfo Identifier: | 74751679 |
NCBI Gene ID: | 3140 |
NCBI Accession: | Q95460.1 |
UniProt Secondary Accession: | Q95460,O97985, O97986, Q53GM1, Q95HB8, Q9MY23, Q9NPL2 Q9TQB3, Q9TQB9, Q9TQK3, A8K2V9, B4E3B1, |
UniProt Related Accession: | Q95460 |
Molecular Weight: | 25,190 Da |
NCBI Full Name: | Major histocompatibility complex class I-related gene protein |
NCBI Synonym Full Names: | major histocompatibility complex, class I-related |
NCBI Official Symbol: | MR1 |
NCBI Official Synonym Symbols: | HLALS |
NCBI Protein Information: | major histocompatibility complex class I-related gene protein |
UniProt Protein Name: | Major histocompatibility complex class I-related gene protein |
UniProt Synonym Protein Names: | Class I histocompatibility antigen-like protein |
Protein Family: | Major histocompatibility complex class I-related gene protein |
UniProt Gene Name: | MR1 |
UniProt Entry Name: | HMR1_HUMAN |
Antibodies | ELISA Kits |
Anti-MR1 Antibody (CAB8051) | Human Major histocompatibility complex class I-related gene protein (MR1) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |