MPG Antibody (PACO15821)
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주문- SKU:
- PACO15821
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MPG Antibody (PACO15821) |
Antibody SKU: | PACO15821 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human MPG |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-7: 231 cells, 293T cells, Lovo cells, hepG2 cells, A549 cells, PC3 cells, A172 cells, Primary antibody: PACO15821(MPG Antibody) at dilution 1/1500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
Background: | Maintenance of DNA sequences is necessary for vertebrates and other life. DNA is under constant stress by a plethora of DNA-damaging agents present in both the environment and within cells. The potentially deleterious effects of DNA lesions in cells are elegantly resolved by sophisticated DNA repair systems, including base excision repair (BER), nucleotide excision repair (NER) and DNA repair methyltransferase (MTase). Methylated bases, such as 3-methyladenine (3MeA) and 7-methylguanine (7MeG) can be formed by agents in the environment and by endogenous cellular processes. Consequently, in the absence of exposure to environmental agents, DNA methylation damage can be incurred on the genomic DNA of normal mammalian cells. DNA N-glycosylases are base excision-repair proteins that locate and cleave damaged bases from DNA as the first step in restoring the sequence. |
Synonyms: | N-methylpurine-DNA glycosylase |
UniProt Protein Function: | MPG: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. Belongs to the DNA glycosylase MPG family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.2.2.21; Hydrolase; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: nucleoplasm Molecular Function:protein binding; alkylbase DNA N-glycosylase activity; DNA-3-methyladenine glycosylase I activity; damaged DNA binding Biological Process: DNA dealkylation; base-excision repair, AP site formation; depurination; base-excision repair; DNA repair |
UniProt Code: | P29372 |
NCBI GenInfo Identifier: | 206729922 |
NCBI Gene ID: | 4350 |
NCBI Accession: | P29372.3 |
UniProt Secondary Accession: | P29372,Q13770, Q15275, Q15961, Q5J9I4, Q96BZ6, Q96S33 Q9NNX5, G5E9E2, |
UniProt Related Accession: | P29372 |
Molecular Weight: | 298 |
NCBI Full Name: | DNA-3-methyladenine glycosylase |
NCBI Synonym Full Names: | N-methylpurine-DNA glycosylase |
NCBI Official Symbol: | MPG |
NCBI Official Synonym Symbols: | AAG; MDG; ADPG; APNG; Mid1; anpg; PIG11; PIG16; CRA36.1 |
NCBI Protein Information: | DNA-3-methyladenine glycosylase; 3-alkyladenine DNA glycosylase; 3-methyladenine DNA glycosidase; proliferation-inducing protein 11; proliferation-inducing protein 16; N-methylpurine-DNA glycosylase, MPG; CRA36.1 (3-methyl-adenine DNA glycosylase); 3' end of the Mid1 gene, localized 68 kb upstream the humanzeta globin gene on 16p |
UniProt Protein Name: | DNA-3-methyladenine glycosylase |
UniProt Synonym Protein Names: | 3-alkyladenine DNA glycosylase; 3-methyladenine DNA glycosidase; ADPG; N-methylpurine-DNA glycosylase |
Protein Family: | DNA-3-methyladenine glycosylase |
UniProt Gene Name: | MPG |
UniProt Entry Name: | 3MG_HUMAN |
Antibodies |
Anti-MPG Antibody (CAB14025) |
Anti-MPG Antibody (CAB5410) |
Anti-MPG Antibody (CAB18070)[KO Validated] |
MPG Antibody (PACO10551) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |