CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I transmembrane glycoprotein belonging to the CTX family of the Ig superfamily, and is essential for normal cardiac development in the mouse. Proposed as a homophilic cell adhesion molecule, CXADR is a component of the epithelial apical junction complex that is essential for the tight junction integrity, and probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN). Mature mouse CXADR structrually comprises a 218 aa extracellular domain (ECD) with a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment and a 107 aa intracellular domain, among which,D1 is thought to be responsible for homodimer formation in trans within tight junctions. The ECD of mouse CXADR shares 97%, 90% sequence identity with the corresponding regions of rat, human CXADR.
Product Name:
Mouse CXADR/CAR Recombinant Protein (RPES0720)
Product Code:
RPES0720
Size:
50µg
Species:
Mouse
Expressed Host:
HEK293 Cells
Synonyms:
Coxsackievirus and adenovirus receptor homolog,CAR,Cxadr,CVB3 BP,MCVADR
Accession:
NP_001020363.1
Sequence:
Met1-Gly237
Fusion tag:
C-Fc-His
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the mouse Cxadr (NP_001020363.1) (Met1-Gly237) was expressed with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus (Fc-his).
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
52 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
system_update_alt데이터시트Human CXADR/CAR Recombinant Protein CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I transmembrane glycoprotein belonging to the CTX fam