Mouse BACE2/Beta secretase 2 Recombinant Protein (RPES3080)

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SKU:
RPES3080
Product type:
Recombinant Protein
Host species:
HEK293 Cells
Reactivity:
Mouse
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Description

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Mouse BACE2/Beta secretase 2 Recombinant Protein

BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.

Product Name:Mouse BACE2/Beta secretase 2 Recombinant Protein (RPES3080)
Product Code:RPES3080
Size:20µg
Species:Mouse
Expressed Host:HEK293 Cells
Synonyms:1110059C24Rik,AEPLC,AI850424,ALP56,ARP1,ASP21,BAE2,CDA13,CEAP1,DRAP
Accession:Q9JL18
Sequence:Met1-Pro462
Fusion tag:C-His
Activity:Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 .The specific activity is >50 pmoles/min/µg.
Endotoxin:<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:A DNA sequence encoding the mouse BACE2 (Q9JL18) (Met1-Pro462) was expressed with a C-terminal polyhistidine tag.
Purity:> 95 % as determined by SDS-PAGE
Mol Mass:49.2 kDa
AP Mol Mass:55 kDa
Formulation:Lyophilized from sterile PBS, pH 7.4
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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