MMP25 Antibody (PACO18232)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO18232
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MMP25 Antibody (PACO18232) |
Antibody SKU: | PACO18232 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human MMP25 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18232(MMP25 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 10+12%SDS-PAGE, Lysate: 40 μg, Lane: 823 cells, Primary antibody: PACO18232(MMP25 Antibody) at dilution 1/1300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18232(MMP25 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. |
Synonyms: | matrix metallopeptidase 25 |
UniProt Protein Function: | MMP25: May activate progelatinase A. Belongs to the peptidase M10A family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.4.24.-; Membrane protein, GPI anchor; Cell surface; Activator; Protease Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: proteinaceous extracellular matrix; membrane; plasma membrane; integral to membrane Molecular Function:zinc ion binding; metalloendopeptidase activity; calcium ion binding Biological Process: hard palate development; proteolysis; inflammatory response |
NCBI Summary: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NPA2 |
NCBI GenInfo Identifier: | 12585274 |
NCBI Gene ID: | 64386 |
NCBI Accession: | Q9NPA2.1 |
UniProt Secondary Accession: | Q9NPA2,Q9H3Q0, D3DUA8, |
UniProt Related Accession: | Q9NPA2 |
Molecular Weight: | |
NCBI Full Name: | Matrix metalloproteinase-25 |
NCBI Synonym Full Names: | matrix metallopeptidase 25 |
NCBI Official Symbol: | MMP25 |
NCBI Official Synonym Symbols: | MMP20; MMPL1; MMP-25; MMP20A; MT6MMP; MTMMP6; MT-MMP6; MT6-MMP; MT-MMP 6 |
NCBI Protein Information: | matrix metalloproteinase-25; leukolysin; matrix metalloproteinase 20; matrix metalloproteinase 25; matrix metallopeptidase-like 1; matrix metalloproteinase-like 1; membrane-type 6 matrix metalloproteinase; membrane-type matrix metalloproteinase 6; membrane-type-6 matrix metalloproteinase |
UniProt Protein Name: | Matrix metalloproteinase-25 |
UniProt Synonym Protein Names: | Leukolysin; Membrane-type matrix metalloproteinase 6; MT-MMP 6; MTMMP6; Membrane-type-6 matrix metalloproteinase; MT6-MMP; MT6MMP |
Protein Family: | Matrix metalloproteinase |
UniProt Gene Name: | MMP25 |
UniProt Entry Name: | MMP25_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |