MMP11 Antibody (PACO54434)
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주문- SKU:
- PACO54434
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MMP11 Antibody (PACO54434) |
Antibody SKU: | PACO54434 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Stromelysin-3 protein (198-377AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescent analysis of A549 cells using PACO54434 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | May play an important role in the progression of epithelial malignancies. |
Synonyms: | Stromelysin-3 (SL-3) (ST3) (EC 3.4.24) (Matrix metalloproteinase-11) (MMP-11), MMP11, STMY3 |
UniProt Protein Function: | MMP11: May play an important role in the progression of epithelial malignancies. Belongs to the peptidase M10A family. |
UniProt Protein Details: | Protein type:Extracellular matrix; Protease; Secreted; EC 3.4.24.-; Secreted, signal peptide Chromosomal Location of Human Ortholog: 22q11.23 Cellular Component: extracellular region; Golgi lumen; proteinaceous extracellular matrix Molecular Function:serine-type endopeptidase activity Biological Process: collagen catabolic process; extracellular matrix disassembly |
NCBI Summary: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008] |
UniProt Code: | P24347 |
NCBI GenInfo Identifier: | 317373418 |
NCBI Gene ID: | 4320 |
NCBI Accession: | P24347.3 |
UniProt Secondary Accession: | P24347,Q5FX24, Q6PEZ6, Q9UC26, |
UniProt Related Accession: | P24347 |
Molecular Weight: | 54,590 Da |
NCBI Full Name: | Stromelysin-3 |
NCBI Synonym Full Names: | matrix metallopeptidase 11 |
NCBI Official Symbol: | MMP11 |
NCBI Official Synonym Symbols: | ST3; SL-3; STMY3 |
NCBI Protein Information: | stromelysin-3 |
UniProt Protein Name: | Stromelysin-3 |
UniProt Synonym Protein Names: | Matrix metalloproteinase-11; MMP-11 |
Protein Family: | Stromelysin |
UniProt Gene Name: | MMP11 |
UniProt Entry Name: | MMP11_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |