MLLT10 Antibody (PACO21809)
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주문- SKU:
- PACO21809
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MLLT10 Antibody (PACO21809) |
Antibody SKU: | PACO21809 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from internal of human AF10. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Matsuoka S., Science 316:1160-1166(2007). |
Clonality: | Polyclonal |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from COLO205 cells and Jurkat cells, using AF10 antibody. |
Synonyms: | Protein AF-10; MLLT10; AF10; |
UniProt Protein Function: | MLLT10: Probably involved in transcriptional regulation. In vitro or as fusion protein with MLL has transactivation activity. Binds to cruciform DNA. A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with MLL/HRX. The result is a rogue activator protein. A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 10p12 Cellular Component: cytoplasm; nucleoplasm Molecular Function:protein binding Biological Process: positive regulation of transcription from RNA polymerase II promoter Disease: Leukemia, Acute Myeloid |
NCBI Summary: | This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010] |
UniProt Code: | P55197 |
NCBI GenInfo Identifier: | 527504034 |
NCBI Gene ID: | 8028 |
NCBI Accession: | P55197.2 |
UniProt Secondary Accession: | P55197,Q5JT37, Q5VX90, Q66K63, B1ANA8, |
UniProt Related Accession: | P55197 |
Molecular Weight: | 20,047 Da |
NCBI Full Name: | Protein AF-10 |
NCBI Synonym Full Names: | myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 |
NCBI Official Symbol: | MLLT10 |
NCBI Official Synonym Symbols: | AF10 |
NCBI Protein Information: | protein AF-10 |
UniProt Protein Name: | Protein AF-10 |
UniProt Synonym Protein Names: | ALL1-fused gene from chromosome 10 protein |
Protein Family: | Protein |
UniProt Gene Name: | MLLT10 |
UniProt Entry Name: | AF10_HUMAN |
Antibodies | ELISA Kits |
Anti-MLLT10 Antibody (CAB14260) | AF10 Colorimetric Cell-Based ELISA |
MLLT10 Antibody (PACO00374) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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