MLF1 Antibody (PACO44836)
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주문- SKU:
- PACO44836
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MLF1 Antibody (PACO44836) |
Antibody SKU: | PACO44836 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Myeloid leukemia factor 1 protein (1-268AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: MLF1 antibody at 4.05µg/ml + Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 31, 24, 34, 28, 30 kDa. Observed band size: 31 kDa.. | |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO44836 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO44836 at dilution of 1:100. |
Background: | Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. |
Synonyms: | Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1), MLF1 |
UniProt Protein Function: | MLF1: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM. Belongs to the MLF family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 3q25.1 Cellular Component: cytoplasm; nucleus Molecular Function:DNA binding; protein binding; protein domain specific binding Biological Process: cell cycle arrest; myeloid progenitor cell differentiation; transcription, DNA-dependent Disease: Leukemia, Acute Myeloid |
NCBI Summary: | This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010] |
UniProt Code: | P58340 |
NCBI GenInfo Identifier: | 17368170 |
NCBI Gene ID: | 4291 |
NCBI Accession: | P58340.1 |
UniProt Secondary Accession: | P58340,Q2TLE3, Q2TLE5, Q8N8F8, Q96MH1, E9PEU9, |
UniProt Related Accession: | P58340 |
Molecular Weight: | 29,095 Da |
NCBI Full Name: | Myeloid leukemia factor 1 |
NCBI Synonym Full Names: | myeloid leukemia factor 1 |
NCBI Official Symbol: | MLF1 |
NCBI Protein Information: | myeloid leukemia factor 1 |
UniProt Protein Name: | Myeloid leukemia factor 1 |
UniProt Synonym Protein Names: | Myelodysplasia-myeloid leukemia factor 1 |
Protein Family: | Myeloid leukemia factor |
UniProt Gene Name: | MLF1 |
UniProt Entry Name: | MLF1_HUMAN |
Antibodies |
Anti-MLF1 Antibody (CAB13329) |
Anti-MLF1 Antibody (CAB8012) |
MLF1 Antibody (PACO04333) |
MLF1 Antibody (PACO10507) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |