MKL1 Antibody (PACO62587)
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주문- SKU:
- PACO62587
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MKL1 Antibody (PACO62587) |
Antibody SKU: | PACO62587 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human MKL/myocardin-like protein 1 protein (674-812AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescence staining of Hela cells with PACO62587 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity). |
Synonyms: | MKL/myocardin-like protein 1 (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) (Myocardin-related transcription factor A) (MRTF-A), MKL1, KIAA1438 MAL |
UniProt Protein Function: | MKL1: Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation. Forms with SCAI and SRF a nuclear ternary complex which binds the CArG consensus motif (CArG box) on DNA via SRF. Interacts with ACTB; interaction with ACTB prevents interaction with SCAI. Interacts with MKL2. Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain. |
UniProt Protein Details: | Protein type:Oncoprotein; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 22q13 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:actin binding; actin monomer binding; leucine zipper domain binding; protein binding; transcription coactivator activity Biological Process: positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation |
NCBI Summary: | The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
UniProt Code: | Q969V6 |
NCBI GenInfo Identifier: | 32363202 |
NCBI Gene ID: | 57591 |
NCBI Accession: | Q969V6.1 |
UniProt Secondary Accession: | Q969V6,Q8TCL1, Q96SC5, Q96SC6, Q9P2B0, |
UniProt Related Accession: | Q969V6 |
Molecular Weight: | 98,919 Da |
NCBI Full Name: | MKL/myocardin-like protein 1 |
NCBI Synonym Full Names: | megakaryoblastic leukemia (translocation) 1 |
NCBI Official Symbol: | MKL1 |
NCBI Official Synonym Symbols: | MAL; BSAC; MRTF-A |
NCBI Protein Information: | MKL/myocardin-like protein 1 |
UniProt Protein Name: | MKL/myocardin-like protein 1 |
UniProt Synonym Protein Names: | Megakaryoblastic leukemia 1 protein; Megakaryocytic acute leukemia protein; Myocardin-related transcription factor A; MRTF-A |
Protein Family: | MKL/myocardin-like protein |
UniProt Gene Name: | MKL1 |
UniProt Entry Name: | MKL1_HUMAN |
Antibodies |
Anti-MKL1 Antibody (CAB12598) |
Anti-MKL1 Antibody (CAB14212) |
Anti-MKL1 Antibody (CAB8504) |
MKL1 Antibody (PACO01111) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |