MITF Antibody (PACO14706)
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주문- SKU:
- PACO14706
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | MITF Antibody (PACO14706) |
Antibody SKU: | PACO14706 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human MITF |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: 231 cells, Primary antibody: PACO14706(MITF Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
Background: | This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Synonyms: | microphthalmia-associated transcription factor |
UniProt Protein Function: | MITF: a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. Plays a critical role in the differentiation of various cell types including neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. Two isoforms are known: the M-isoform is expressed exclusively in melanocytes, while the A-isoform has a much broader range of expression. Mutations in MITF can lead to Waardenburg syndrome. Ten alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Transcription factor; Oncoprotein; DNA-binding Chromosomal Location of Human Ortholog: 3p14.2-p14.1 Cellular Component: protein complex; nucleus Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; protein dimerization activity; protein binding; chromatin binding Biological Process: transcription from RNA polymerase II promoter; regulation of osteoclast differentiation; camera-type eye development; cell fate commitment; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; melanocyte differentiation; protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; osteoclast differentiation; bone remodeling; regulation of cell proliferation Disease: Waardenburg Syndrome, Type 2a; Albinism, Ocular, With Sensorineural Deafness; Melanoma, Cutaneous Malignant, Susceptibility To, 8; Tietz Syndrome |
NCBI Summary: | This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | O75030 |
NCBI GenInfo Identifier: | 13124344 |
NCBI Gene ID: | 4286 |
NCBI Accession: | O75030.2 |
UniProt Secondary Accession: | O75030,Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8, B4DJL2 D3K197, E9PFN0, |
UniProt Related Accession: | O75030 |
Molecular Weight: | 526 |
NCBI Full Name: | Microphthalmia-associated transcription factor |
NCBI Synonym Full Names: | microphthalmia-associated transcription factor |
NCBI Official Symbol: | MITF |
NCBI Official Synonym Symbols: | MI; WS2; CMM8; WS2A; bHLHe32 |
NCBI Protein Information: | microphthalmia-associated transcription factor; class E basic helix-loop-helix protein 32 |
UniProt Protein Name: | Microphthalmia-associated transcription factor |
UniProt Synonym Protein Names: | Class E basic helix-loop-helix protein 32; bHLHe32 |
Protein Family: | Microphthalmia-associated transcription factor |
UniProt Gene Name: | MITF |
UniProt Entry Name: | MITF_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |