MGAT1 Antibody (PACO44266)
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주문- SKU:
- PACO44266
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MGAT1 Antibody (PACO44266) |
Antibody SKU: | PACO44266 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase protein (156-445AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: MGAT1 antibody at 1.18µg/ml + 293T whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 75 kDa. Observed band size: 75 kDa.. | |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO44266 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO44266 at dilution of 1:100. |
Background: | Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. |
Synonyms: | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.101) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I) (GNT-I) (GlcNAc-T I), MGAT1, GGNT1 GLCT1 GLYT1 MGAT |
UniProt Protein Function: | MGAT1: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. Belongs to the glycosyltransferase 13 family. |
UniProt Protein Details: | Protein type:EC 2.4.1.101; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Transferase Chromosomal Location of Human Ortholog: 5q35.3 Cellular Component: Golgi membrane; membrane Molecular Function:acetylglucosaminyltransferase activity; alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity Biological Process: carbohydrate metabolic process |
NCBI Summary: | There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P26572 |
NCBI GenInfo Identifier: | 311033399 |
NCBI Gene ID: | 4245 |
NCBI Accession: | P26572.2 |
UniProt Secondary Accession: | P26572,Q6IBE3, A8K404, B3KRU8, D3DWR1, |
UniProt Related Accession: | P26572 |
Molecular Weight: | 51kDa |
NCBI Full Name: | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
NCBI Synonym Full Names: | mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase |
NCBI Official Symbol: | MGAT1 |
NCBI Official Synonym Symbols: | GnTI; MGAT; GLCT1; GLYT1; GNT-1; GNT-I; GLCNAC-TI |
NCBI Protein Information: | alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
UniProt Protein Name: | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
UniProt Synonym Protein Names: | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I; GNT-I; GlcNAc-T I |
UniProt Gene Name: | MGAT1 |