UniProt Protein Function: | SURF5: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 22 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 9q34.2 Cellular Component: cytoplasm; Srb-mediator complex Molecular Function:protein binding Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013] |
UniProt Code: | Q15528 |
NCBI GenInfo Identifier: | 6175074 |
NCBI Gene ID: | 6837 |
NCBI Accession: | Q15528.2 |
UniProt Secondary Accession: | Q15528,O76072, Q5T8U0, B3KW83, B3KWX4, |
UniProt Related Accession: | Q15528 |
Molecular Weight: | 16,480 Da |
NCBI Full Name: | Mediator of RNA polymerase II transcription subunit 22 |
NCBI Synonym Full Names: | mediator complex subunit 22 |
NCBI Official Symbol: | MED22 |
NCBI Official Synonym Symbols: | MED24; SURF5; surf-5 |
NCBI Protein Information: | mediator of RNA polymerase II transcription subunit 22; surfeit locus protein 5 |
UniProt Protein Name: | Mediator of RNA polymerase II transcription subunit 22 |
UniProt Synonym Protein Names: | Mediator complex subunit 22; Surfeit locus protein 5; Surf-5 |
Protein Family: | Mediator of RNA polymerase II transcription |
UniProt Gene Name: | MED22 |
UniProt Entry Name: | MED22_HUMAN |