MED14 Antibody (PACO20755)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO20755
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MED14 Antibody (PACO20755) |
Antibody SKU: | PACO20755 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human MED14 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20755(MED14 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. |
Synonyms: | mediator complex subunit 14 |
UniProt Protein Function: | Trap170: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 14 family. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: Xp11.4 Cellular Component: membrane; nucleoplasm; nucleus; Srb-mediator complex Molecular Function:protein binding; receptor activity; transcription coactivator activity; transcription cofactor activity Biological Process: androgen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter |
NCBI Summary: | The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008] |
UniProt Code: | O60244 |
NCBI GenInfo Identifier: | 145559461 |
NCBI Gene ID: | 9282 |
NCBI Accession: | O60244.2 |
UniProt Secondary Accession: | O60244,Q4KMR7, Q9UNB3, |
UniProt Related Accession: | O60244 |
Molecular Weight: | 160,607 Da |
NCBI Full Name: | Mediator of RNA polymerase II transcription subunit 14 |
NCBI Synonym Full Names: | mediator complex subunit 14 |
NCBI Official Symbol: | MED14 |
NCBI Official Synonym Symbols: | CSRP; RGR1; CRSP2; EXLM1; CXorf4; CRSP150; DRIP150; TRAP170 |
NCBI Protein Information: | mediator of RNA polymerase II transcription subunit 14 |
UniProt Protein Name: | Mediator of RNA polymerase II transcription subunit 14 |
UniProt Synonym Protein Names: | Activator-recruited cofactor 150 kDa component; ARC150; Cofactor required for Sp1 transcriptional activation subunit 2; CRSP complex subunit 2; Mediator complex subunit 14; RGR1 homolog; hRGR1; Thyroid hormone receptor-associated protein complex 170 kDa component; Trap170; Transcriptional coactivator CRSP150; Vitamin D3 receptor-interacting protein complex 150 kDa component; DRIP150 |
Protein Family: | Mediator of RNA polymerase II transcription |
UniProt Gene Name: | MED14 |
UniProt Entry Name: | MED14_HUMAN |