MECP2 Antibody (PACO22852)
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주문- SKU:
- PACO22852
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MECP2 Antibody (PACO22852) |
Antibody SKU: | PACO22852 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of Hela cell lysate, using diluted at 1:2,000 (lane 1) and 1:5,000 (lane 2). |
Background: | Methyl-CpG-binding protein 2(MeCP2), whose exact function is unclear. It appears to help regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into chromosomes. The MeCP2 protein usually regulates genes involved in brain function, even though this protein is found throughout the body.Within the brain, the MeCP2 protein is important for the function of nerve cells (neurons) and is present in high levels in mature neurons. This protein likely plays a role in maintaining connections (synapses) between neurons, where cell-to-cell communication occurs. Many of the genes that are known to be regulated by the MeCP2 protein play a role in normal brain function, particularly the maintenance of synapses. |
Synonyms: | AUTSX3; DKFZp686A24160; MeCp-2 protein; MECP2; methyl CpG binding protein 2 (Rett syndrome) |
UniProt Protein Function: | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). |
NCBI Summary: | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015] |
UniProt Code: | P51608 |
NCBI GenInfo Identifier: | 1708973 |
NCBI Gene ID: | 4204 |
NCBI Accession: | P51608.1 |
UniProt Secondary Accession: | P51608,O15233, Q6QHH9, Q7Z384, |
UniProt Related Accession: | P51608 |
Molecular Weight: | 53,323 Da |
NCBI Full Name: | Methyl-CpG-binding protein 2 |
NCBI Synonym Full Names: | methyl-CpG binding protein 2 |
NCBI Official Symbol: | MECP2 |
NCBI Official Synonym Symbols: | RS; RTS; RTT; PPMX; MRX16; MRX79; MRXSL; AUTSX3; MRXS13 |
NCBI Protein Information: | methyl-CpG-binding protein 2 |
UniProt Protein Name: | Methyl-CpG-binding protein 2 |
Protein Family: | Methyl-CpG-binding protein |
UniProt Gene Name: | MECP2 |
UniProt Entry Name: | MECP2_HUMAN |
Antibodies |
Anti-MECP2 Antibody (CAB0707)[KO Validated] |
Anti-MECP2 Antibody (CAB13328) |
Anti-MECP2 Antibody (CAB5694) |
Anti-MECP2 Antibody (CAB16917) |
MECP2 Antibody (PACO00088) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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