MDK Antibody (PACO14703)
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주문- SKU:
- PACO14703
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | MDK Antibody (PACO14703) |
Antibody SKU: | PACO14703 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human MDK |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO14703(MDK Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14703(MDK Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid, The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. |
Synonyms: | midkine (neurite growth-promoting factor 2) |
UniProt Protein Function: | MDK: Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development. Belongs to the pleiotrophin family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: cell projection; cytoplasm; extracellular region Molecular Function:heparin binding; growth factor activity Biological Process: response to drug; nervous system development; cell migration; Notch signaling pathway; dentate gyrus development; behavioral fear response; cerebellar granular layer development; short-term memory; adrenal gland development; positive regulation of transcription, DNA-dependent; response to glucocorticoid stimulus; signal transduction; positive regulation of cell division; response to wounding; cerebral cortex development; negative regulation of neuron apoptosis; cell differentiation; defecation; regulation of behavior |
NCBI Summary: | This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012] |
UniProt Code: | P21741 |
NCBI GenInfo Identifier: | 127116 |
NCBI Gene ID: | 4192 |
NCBI Accession: | P21741.1 |
UniProt Secondary Accession: | P21741,Q2LEK4, Q9UCC7, |
UniProt Related Accession: | P21741 |
Molecular Weight: | 9,512 Da |
NCBI Full Name: | Midkine |
NCBI Synonym Full Names: | midkine (neurite growth-promoting factor 2) |
NCBI Official Symbol: | MDK |
NCBI Official Synonym Symbols: | MK; ARAP; NEGF2 |
NCBI Protein Information: | midkine; retinoic acid inducible factor; amphiregulin-associated protein; midgestation and kidney protein; neurite outgrowth-promoting factor 2 |
UniProt Protein Name: | Midkine |
UniProt Synonym Protein Names: | Amphiregulin-associated protein; ARAP; Midgestation and kidney protein; Neurite outgrowth-promoting factor 2; Neurite outgrowth-promoting protein |
Protein Family: | Midkine |
UniProt Gene Name: | MDK |
UniProt Entry Name: | MK_HUMAN |
Antibodies | ELISA Kits |
Anti-MDK Antibody (CAB0251) | Human MK (Midkine) CLIA Kit (HUES01193) |
MDK Antibody (PACO01068) | Human Midkine (MDK) ELISA Kit |
MDK Antibody (PACO01891) | |
MDK Antibody (PACO10430) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |