UniProt Protein Function: | MDH2: mitochondrial malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. May play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 1.1.1.37; Oxidoreductase Chromosomal Location of Human Ortholog: 7cen-q22 Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; mitochondrial inner membrane; plasma membrane; nucleus Molecular Function:protein self-association; L-malate dehydrogenase activity; malate dehydrogenase (NADP+) activity Biological Process: cellular metabolic process; malate metabolic process; oxaloacetate metabolic process; NADH metabolic process; tricarboxylic acid cycle; carbohydrate metabolic process; glucose metabolic process; pathogenesis; cellular carbohydrate metabolic process; internal protein amino acid acetylation; gluconeogenesis |
NCBI Summary: | Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] |
UniProt Code: | P40926 |
NCBI GenInfo Identifier: | 215274114 |
NCBI Gene ID: | 4191 |
NCBI Accession: | P40926.3 |
UniProt Secondary Accession: | P40926,O43682, A8K414, B2RE78, B4DE44, E9PDB2, |
UniProt Related Accession: | P40926 |
Molecular Weight: | 338 |
NCBI Full Name: | Malate dehydrogenase, mitochondrial |
NCBI Synonym Full Names: | malate dehydrogenase 2, NAD (mitochondrial) |
NCBI Official Symbol: | MDH2 |
NCBI Official Synonym Symbols: | MDH; MOR1; M-MDH; MGC:3559 |
NCBI Protein Information: | malate dehydrogenase, mitochondrial |
UniProt Protein Name: | Malate dehydrogenase, mitochondrial |
Protein Family: | Malate dehydrogenase |
UniProt Gene Name: | MDH2 |
UniProt Entry Name: | MDHM_HUMAN |