MCM5 Antibody (PACO14687)
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주문- SKU:
- PACO14687
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MCM5 Antibody (PACO14687) |
Antibody SKU: | PACO14687 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human MCM5 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO14687(MCM5 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-5: HepG2 cells, K562 cells, Jurkat cells, 231 cells, hela cells, Primary antibody: PACO14687(MCM5 Antibody) at dilution 1/475, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO14687(MCM5 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. |
Synonyms: | minichromosome maintenance complex component 5 |
UniProt Protein Function: | MCM5: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Interacts with MCMBP. Belongs to the MCM family. |
UniProt Protein Details: | Protein type:Cell cycle regulation; EC 3.6.4.12 Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: nucleoplasm; MCM complex; membrane; nucleus Molecular Function:DNA helicase activity; protein binding; DNA binding; ATP binding Biological Process: DNA replication initiation; DNA strand elongation during DNA replication; mitotic cell cycle; DNA replication; DNA duplex unwinding; G1/S transition of mitotic cell cycle |
NCBI Summary: | The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008] |
UniProt Code: | P33992 |
NCBI GenInfo Identifier: | 19858646 |
NCBI Gene ID: | 4174 |
NCBI Accession: | P33992.5 |
UniProt Secondary Accession: | P33992,O60785, Q14578, Q9BTJ4, Q9BWL8, |
UniProt Related Accession: | P33992 |
Molecular Weight: | 82,286 Da |
NCBI Full Name: | DNA replication licensing factor MCM5 |
NCBI Synonym Full Names: | minichromosome maintenance complex component 5 |
NCBI Official Symbol: | MCM5 |
NCBI Official Synonym Symbols: | CDC46; P1-CDC46 |
NCBI Protein Information: | DNA replication licensing factor MCM5; CDC46 homolog; minichromosome maintenance deficient 5 (cell division cycle 46); MCM5 minichromosome maintenance deficient 5, cell division cycle 46 |
UniProt Protein Name: | DNA replication licensing factor MCM5 |
UniProt Synonym Protein Names: | CDC46 homolog; P1-CDC46 |
Protein Family: | Minichromosome maintenance protein |
UniProt Gene Name: | MCM5 |
UniProt Entry Name: | MCM5_HUMAN |
Antibodies | ELISA Kits |
Anti-MCM5 Antibody (CAB13514) | MCM5 Colorimetric Cell-Based ELISA Kit |
Anti-MCM5 Antibody (CAB5556) | |
Anti-MCM5 Antibody (CAB5008) | |
MCM5 Antibody (PACO06338) | |
MCM5 Antibody (PACO10422) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |