MAT2B Antibody (PACO51114)
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주문- SKU:
- PACO51114
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MAT2B Antibody (PACO51114) |
Antibody SKU: | PACO51114 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:2000, IF:1:50-1:200 |
Species Reactivity: | Human, Rat |
Immunogen: | Recombinant Human Methionine adenosyltransferase 2 subunit β protein (85-143AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescent analysis of HepG2 cells using PACO51114 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Western Blot. Positive WB detected in: Rat heart tissue. All lanes: MAT2B antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 38, 37, 29, 35, 10 kDa. Observed band size: 38 kDa. |
Background: | Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine inhibition. |
Synonyms: | Methionine adenosyltransferase 2 subunit β (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase), MAT2B, TGR |
UniProt Protein Function: | MAT2B: Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S- adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S- adenosylmethionine inhibition. Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transferase; Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - cysteine and methionine Chromosomal Location of Human Ortholog: 5q34 Cellular Component: methionine adenosyltransferase complex; mitochondrion; intracellular; cytosol; nucleus Molecular Function:enzyme binding; methionine adenosyltransferase regulator activity Biological Process: methylation; regulation of catalytic activity; xenobiotic metabolic process; S-adenosylmethionine biosynthetic process; one-carbon compound metabolic process |
NCBI Summary: | The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012] |
UniProt Code: | Q9NZL9 |
NCBI GenInfo Identifier: | 74719662 |
NCBI Gene ID: | 27430 |
NCBI Accession: | Q9NZL9.1 |
UniProt Secondary Accession: | Q9NZL9,Q1WAI7, Q27J92, Q3LIE8, Q567T7, Q6NYC7, Q9BS89 Q9H3E1, Q9UJ54, B2R5Y6, |
UniProt Related Accession: | Q9NZL9 |
Molecular Weight: | 334 |
NCBI Full Name: | Methionine adenosyltransferase 2 subunit beta |
NCBI Synonym Full Names: | methionine adenosyltransferase II, beta |
NCBI Official Symbol: | MAT2B |
NCBI Official Synonym Symbols: | TGR; MAT-II; SDR23E1; MATIIbeta; Nbla02999 |
NCBI Protein Information: | methionine adenosyltransferase 2 subunit beta; MAT II beta; putative protein product of Nbla02999; dTDP-4-keto-6-deoxy-D-glucose 4-reductase; putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase; short chain dehydrogenase/reductase family 23E, member 1; bet |
UniProt Protein Name: | Methionine adenosyltransferase 2 subunit beta |
UniProt Synonym Protein Names: | Methionine adenosyltransferase II beta; MAT II beta; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase |
Protein Family: | Methionine adenosyltransferase |
UniProt Gene Name: | MAT2B |
UniProt Entry Name: | MAT2B_HUMAN |