MASP2 Antibody (PACO18191)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO18191
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MASP2 Antibody (PACO18191) |
Antibody SKU: | PACO18191 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human MASP2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18191(MASP2 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18191(MASP2 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases. |
Synonyms: | mannan-binding lectin serine peptidase 2 |
UniProt Protein Function: | MASP2: Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. Defects in MASP2 are the cause of MASP2 deficiency (MASPD). MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.4.21.104; Protease; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1p36.3-p36.2 Cellular Component: extracellular region Molecular Function:peptidase activity; protein binding; serine-type endopeptidase activity; complement component C4b binding; calcium ion binding; calcium-dependent protein binding Biological Process: innate immune response; complement activation, lectin pathway; proteolysis; complement activation, classical pathway; complement activation Disease: Masp2 Deficiency |
NCBI Summary: | The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00187 |
NCBI GenInfo Identifier: | 21264363 |
NCBI Gene ID: | 10747 |
NCBI Accession: | NP_006601.2 |
UniProt Secondary Accession: | O00187,O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498 Q9H499, Q9UBP3, Q9UC48, A8K458, A8MWJ2, |
UniProt Related Accession: | O00187 |
Molecular Weight: | 76 kDa |
NCBI Full Name: | mannan-binding lectin serine protease 2 isoform 1 preproprotein |
NCBI Synonym Full Names: | mannan-binding lectin serine peptidase 2 |
NCBI Official Symbol: | MASP2 |
NCBI Official Synonym Symbols: | sMAP; MAP19; MASP-2; MASP1P1 |
NCBI Protein Information: | mannan-binding lectin serine protease 2 |
UniProt Protein Name: | Mannan-binding lectin serine protease 2 |
UniProt Synonym Protein Names: | MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2; MASP-2 |
Protein Family: | Mannan-binding lectin serine protease |
UniProt Gene Name: | MASP2 |
UniProt Entry Name: | MASP2_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |