MARK1 Antibody (PACO15653)
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주문- SKU:
- PACO15653
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MARK1 Antibody (PACO15653) |
Antibody SKU: | PACO15653 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human MARK1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse heart tissue, Mouse brain tissue, Primary antibody: PACO15653(MARK1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. |
Background: | MAP/microtubule affinity-regulating kinase 1 (MARK1) is a 795 amino acid, protein belonging to the CAMK Ser/Thr protein kinase family. MARK1 is thought to play a role in the stability of the microtubule matrix of the cytoskeleton. MARK1 is activated by phosphorylation of Thr215 by LKB1 in complex with STRAD and MO25. Localized to the cytoskeleton, MARK1 contains one kinase-associated (KA1) domain, one protein kinase domain and one UBA domain. Expressed as three isoforms produced by alternative splicing, MARK1 is found with highest levels in brain, skeletal muscle and heart. |
Synonyms: | MAP/microtubule affinity-regulating kinase 1 |
UniProt Protein Function: | MARK1: a member of the CAMKL family of protein kinases. The MARK group of kinases is apparently involved in the control of cell polarity, microtubule stability and cancer. MARK1 forms a tight association with Tau in neurofibrillary tangles in Alzheimer disease tissue. |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC 2.7.11.1; EC 2.7.11.26; CAMK group; CAMKL family; MARK subfamily Chromosomal Location of Human Ortholog: 1q41 Cellular Component: cytoplasm; cytoskeleton; microtubule cytoskeleton; plasma membrane Molecular Function:ATP binding; magnesium ion binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; protein serine/threonine kinase activity; tau-protein kinase activity Biological Process: cytoskeleton organization and biogenesis; neuron migration; protein amino acid phosphorylation; Wnt receptor signaling pathway |
UniProt Code: | Q9P0L2 |
NCBI GenInfo Identifier: | 124056494 |
NCBI Gene ID: | 4139 |
NCBI Accession: | Q9P0L2.2 |
UniProt Secondary Accession: | Q9P0L2,Q2HIY1, Q5VTF9, Q5VTG0, Q96SW9, Q9P251, D3DTB0 D3DTB1, |
UniProt Related Accession: | Q9P0L2 |
Molecular Weight: | 84,911 Da |
NCBI Full Name: | Serine/threonine-protein kinase MARK1 |
NCBI Synonym Full Names: | microtubule affinity regulating kinase 1 |
NCBI Official Symbol: | MARK1 |
NCBI Official Synonym Symbols: | MARK; Par1c; Par-1c |
NCBI Protein Information: | serine/threonine-protein kinase MARK1 |
UniProt Protein Name: | Serine/threonine-protein kinase MARK1 |
UniProt Synonym Protein Names: | MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | MARK1 |
UniProt Entry Name: | MARK1_HUMAN |