UniProt Protein Function: | MLK3: a TKL kinase of the MLK family. Has an amino-terminal SH3 domain followed by the kinase domain, two leucine zipper domains, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-terminal region. Phosphorylates IkappaB and activates SEK1 and MKK7. |
UniProt Protein Details: | Protein type:EC 2.7.11.25; Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; MLK subfamily Chromosomal Location of Human Ortholog: 11q13.1-q13.3 Cellular Component: centrosome; cytoplasm; membrane; microtubule Molecular Function:ATP binding; identical protein binding; JUN kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; Rac GTPase binding Biological Process: activation of JNK activity; activation of JNKK activity; activation of MAPK activity; cell death; cell proliferation; JNK cascade; microtubule-based process; peptidyl-tyrosine phosphorylation; positive regulation of JNK activity; positive regulation of JNK cascade; positive regulation of neuron apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation |
NCBI Summary: | The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q16584 |
NCBI GenInfo Identifier: | 71153819 |
NCBI Gene ID: | 4296 |
NCBI Accession: | Q16584.1 |
UniProt Secondary Accession: | Q16584,Q53H00, Q59F06, Q6P2G4, B4DS76, |
UniProt Related Accession: | Q16584 |
Molecular Weight: | 65,344 Da |
NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 11 |
NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 11 |
NCBI Official Symbol: | MAP3K11 |
NCBI Official Synonym Symbols: | MLK3; PTK1; SPRK; MLK-3; MEKK11 |
NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 11 |
UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 11 |
UniProt Synonym Protein Names: | Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase |
UniProt Gene Name: | MAP3K11 |
UniProt Entry Name: | M3K11_HUMAN |