MAFB Antibody (PACO59581)
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주문- SKU:
- PACO59581
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MAFB Antibody (PACO59581) |
Antibody SKU: | PACO59581 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Transcription factor MafB protein (168-323AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: 293T whole cell lysate, Raw264.7 whole cell lysate. All lanes: MAFB antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 36 kDa. Observed band size: 36 kDa. |
Background: | Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet β cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. |
Synonyms: | Transcription factor MafB (Maf-B) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B), MAFB, KRML |
UniProt Protein Function: | MAFB: Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Defects in MAFB are the cause of multicentric carpotarsal osteolysis syndrome (MCTO). MCTO is a rare skeletal disorder, usually presenting in early childhood with a clinical picture mimicking juvenile rheumatoid arthritis. Progressive destruction of the carpal and tarsal bone usually occurs and other bones may also be involved. Chronic renal failure is a frequent component of the syndrome. Mental retardation and minor facial anomalies have been noted in some patients. Belongs to the bZIP family. Maf subfamily. |
UniProt Protein Details: | Protein type:DNA-binding; Tumor suppressor; Transcription factor; Oncoprotein Chromosomal Location of Human Ortholog: 20q12 Molecular Function:protein binding; transcription factor binding Biological Process: negative regulation of erythrocyte differentiation; negative regulation of osteoclast differentiation; nervous system development; regulation of transcription from RNA polymerase II promoter; sensory organ development Disease: Multicentric Carpotarsal Osteolysis Syndrome |
NCBI Summary: | The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y5Q3 |
NCBI GenInfo Identifier: | 21759268 |
NCBI Gene ID: | 9935 |
NCBI Accession: | Q9Y5Q3.2 |
UniProt Secondary Accession: | Q9Y5Q3,Q9H1F1, B3KNE1, |
UniProt Related Accession: | Q9Y5Q3 |
Molecular Weight: | 35,792 Da |
NCBI Full Name: | Transcription factor MafB |
NCBI Synonym Full Names: | MAF bZIP transcription factor B |
NCBI Official Symbol: | MAFB |
NCBI Official Synonym Symbols: | KRML; MCTO |
NCBI Protein Information: | transcription factor MafB |
UniProt Protein Name: | Transcription factor MafB |
UniProt Synonym Protein Names: | V-maf musculoaponeurotic fibrosarcoma oncogene homolog B |
Protein Family: | Transcription factor |
UniProt Gene Name: | MAFB |
UniProt Entry Name: | MAFB_HUMAN |
Antibodies |
Anti-MAFB Antibody (CAB10077) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |