LYVE1 Antibody (PACO51274)
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주문- SKU:
- PACO51274
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | LYVE1 Antibody (PACO51274) |
Antibody SKU: | PACO51274 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Lymphatic vessel endothelial hyaluronic acid, receptor 1 protein (20-238AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO51274 at dilution of 1:100. | |
Western Blot. Positive WB detected in: Mouse liver tissue, Mouse skeletal muscle tissue. All lanes: LYVE1 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 36 kDa. Observed band size: 36 kDa. | |
Immunofluorescence staining of HepG2 cells with PACO51274 at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. |
Synonyms: | Lymphatic vessel endothelial hyaluronic acid, receptor 1 (LYVE-1) (Cell surface retention sequence-binding protein 1) (CRSBP-1) (Extracellular link domain-containing protein 1) (Hyaluronic acid, receptor), LYVE1, CRSBP1 HAR XLKD1 |
UniProt Protein Function: | XLKD1: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11p15 Cellular Component: membrane; integral to plasma membrane; plasma membrane Molecular Function:transmembrane receptor activity; hyaluronic acid binding; receptor activity Biological Process: anatomical structure morphogenesis; glycosaminoglycan metabolic process; transport; cell-matrix adhesion; carbohydrate metabolic process; response to wounding; pathogenesis; signal transduction; cell motility; hyaluronan metabolic process; hyaluronan catabolic process |
NCBI Summary: | This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y5Y7 |
NCBI GenInfo Identifier: | 115502898 |
NCBI Gene ID: | 10894 |
NCBI Accession: | Q9Y5Y7.2 |
UniProt Secondary Accession: | Q9Y5Y7,Q8TC18, Q9UNF4, |
UniProt Related Accession: | Q9Y5Y7 |
Molecular Weight: | 35,213 Da |
NCBI Full Name: | Lymphatic vessel endothelial hyaluronic acid receptor 1 |
NCBI Synonym Full Names: | lymphatic vessel endothelial hyaluronan receptor 1 |
NCBI Official Symbol: | LYVE1 |
NCBI Official Synonym Symbols: | HAR; XLKD1; LYVE-1; CRSBP-1 |
NCBI Protein Information: | lymphatic vessel endothelial hyaluronic acid receptor 1; cell surface retention sequence binding protein-1; cell surface retention sequence-binding protein 1; extracellular link domain containing 1; extracellular link domain-containing 1; extracellular link domain-containing protein 1 |
UniProt Protein Name: | Lymphatic vessel endothelial hyaluronic acid receptor 1 |
UniProt Synonym Protein Names: | Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1; Hyaluronic acid receptor |
Protein Family: | Lymphatic vessel endothelial hyaluronic acid receptor |
UniProt Gene Name: | LYVE1 |
UniProt Entry Name: | LYVE1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |