LSM11 Antibody (PACO61698)
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주문- SKU:
- PACO61698
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | LSM11 Antibody (PACO61698) |
Antibody SKU: | PACO61698 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human U7 snRNA-associated Sm-like protein LSm11 protein (1-141AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: HepG2 whole cell lysate, Jurkat whole cell lysate, MCF-7 whole cell lysate, HL-60 whole cell lysate, K562 whole cell lysate. All lanes: LSM11 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40 kDa. Observed band size: 40 kDa. | |
Immunofluorescence staining of U251 cells with PACO61698 at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA. |
Synonyms: | U7 snRNA-associated Sm-like protein LSm11, LSM11 |
UniProt Protein Function: | LSM11: Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA. Belongs to the snRNP Sm proteins family. |
UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 5q33.3 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding Biological Process: transcription from RNA polymerase II promoter; histone mRNA metabolic process; histone mRNA 3'-end processing; gene expression; mRNA 3'-end processing; termination of RNA polymerase II transcription |
UniProt Code: | P83369 |
NCBI GenInfo Identifier: | 47117879 |
NCBI Gene ID: | 134353 |
NCBI Accession: | P83369.2 |
UniProt Secondary Accession: | P83369,Q7Z7P0, Q8N975, A0AVQ1, |
UniProt Related Accession: | P83369 |
Molecular Weight: | 360 |
NCBI Full Name: | U7 snRNA-associated Sm-like protein LSm11 |
NCBI Synonym Full Names: | LSM11, U7 small nuclear RNA associated |
NCBI Official Symbol: | LSM11 |
NCBI Protein Information: | U7 snRNA-associated Sm-like protein LSm11 |
UniProt Protein Name: | U7 snRNA-associated Sm-like protein LSm11 |
Protein Family: | U7 snRNA-associated Sm-like protein |
UniProt Gene Name: | LSM11 |
UniProt Entry Name: | LSM11_HUMAN |