LMX1B Antibody (PACO21694)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO21694
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | LMX1B Antibody (PACO21694) |
Antibody SKU: | PACO21694 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from internal of human LMX1B. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from Jurkat cells, 293 cells and HUVEC cells, using LMX1B antibody. |
Background: | Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Vollrath D., Hum. Mol. Genet. 7:1091-1098(1998). |
Synonyms: | LIM homeobox transcription factor 1 beta; LIM/homeobox protein LMX1B; LIM/homeobox protein 1.2; LMX-1.2; LMX1B |
UniProt Protein Function: | LMX1B: Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Defects in LMX1B are the cause of nail-patella syndrome (NPS); also known as onychoosteodysplasia. NPS is a disease that cause abnormal skeletal patterning and renal dysplasia. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell development/differentiation; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 9q33.3 Cellular Component: nucleus Molecular Function:protein binding; zinc ion binding; sequence-specific DNA binding; transcription factor activity Biological Process: collagen fibril organization; transcription, DNA-dependent; in utero embryonic development; multicellular organismal development; neuron migration; cerebellum morphogenesis; limb morphogenesis; neuron differentiation; cell proliferation; organ growth; regulation of transcription, DNA-dependent; dorsal/ventral pattern formation; midbrain development; positive regulation of transcription from RNA polymerase II promoter; central nervous system neuron development Disease: Nail-patella Syndrome |
NCBI Summary: | This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
UniProt Code: | O60663 |
NCBI GenInfo Identifier: | 485956425 |
NCBI Gene ID: | 4010 |
NCBI Accession: | O60663.3 |
UniProt Secondary Accession: | O60663,O75463, Q5JU95, Q6ISC9, F8W7W6, |
UniProt Related Accession: | O60663 |
Molecular Weight: | 402 |
NCBI Full Name: | LIM homeobox transcription factor 1-beta |
NCBI Synonym Full Names: | LIM homeobox transcription factor 1, beta |
NCBI Official Symbol: | LMX1B |
NCBI Official Synonym Symbols: | NPS1; LMX1.2 |
NCBI Protein Information: | LIM homeobox transcription factor 1-beta; LMX-1.2; LIM/homeobox protein 1.2; LIM/homeobox protein LMX1B |
UniProt Protein Name: | LIM homeobox transcription factor 1-beta |
UniProt Synonym Protein Names: | LIM/homeobox protein 1.2; LMX-1.2; LIM/homeobox protein LMX1B |
Protein Family: | LIM/homeobox protein |
UniProt Gene Name: | LMX1B |
UniProt Entry Name: | LMX1B_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |