LMNB1 Antibody (PACO01894)
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주문- SKU:
- PACO01894
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | LMNB1 Antibody |
Antibody SKU: | PACO01894 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the Internal region of human Lamin B1. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | LMNB1; LMN2; LMNB; Lamin-B1 |
UniProt Protein Function: | Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 5q23.2 Cellular Component: nucleoplasm; nuclear membrane; membrane; lamin filament; nuclear inner membrane; nuclear envelope Molecular Function:phospholipase binding; structural molecule activity Biological Process: apoptosis; cell structure disassembly during apoptosis Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant |
NCBI Summary: | This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
UniProt Code: | P20700 |
NCBI GenInfo Identifier: | 125953 |
NCBI Gene ID: | 4001 |
NCBI Accession: | P20700.2 |
UniProt Related Accession: | P20700 |
Molecular Weight: | ~ 68kDa |
NCBI Full Name: | Lamin-B1 |
NCBI Synonym Full Names: | lamin B1 |
NCBI Official Symbol: | LMNB1 |
NCBI Official Synonym Symbols: | LMN; ADLD; LMN2; LMNB |
NCBI Protein Information: | lamin-B1 |
UniProt Protein Name: | Lamin-B1 |
Protein Family: | Light-harvesting protein |
UniProt Gene Name: | LMNB1 |
UniProt Entry Name: | LMNB1_HUMAN |