LILRB4 Antibody (PACO03375)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO03375
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | LILRB4 Antibody |
Antibody SKU: | PACO03375 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | IF:1:200-1:1000 |
Species Reactivity: | Human |
Immunogen: | synthesized peptide derived from the Internal region of human ILT-3. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | LILRB4; ILT3; LIR5; Leukocyte immunoglobulin-like receptor subfamily B member 4; CD85 antigen-like family member K; Immunoglobulin-like transcript 3; ILT-3; Leukocyte immunoglobulin-like receptor 5; LIR-5; Monocyte inhibitory receptor HM18; |
UniProt Protein Function: | LILRB4: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: integral to membrane; plasma membrane Molecular Function:protein binding; receptor activity; antigen binding Biological Process: negative regulation of osteoclast differentiation; immune system process; signal transduction |
NCBI Summary: | This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8NHJ6 |
NCBI GenInfo Identifier: | 322510117 |
NCBI Gene ID: | 11006 |
NCBI Accession: | Q8NHJ6.3 |
UniProt Secondary Accession: | Q8NHJ6,O15468, O75021, Q6FGQ9, Q8N1C7, Q8NHL5, A8MVL8 |
UniProt Related Accession: | Q8NHJ6 |
Molecular Weight: | Calculated: 49 kDaObserved: 45-49kDa |
NCBI Full Name: | Leukocyte immunoglobulin-like receptor subfamily B member 4 |
NCBI Synonym Full Names: | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 |
NCBI Official Symbol: | LILRB4 |
NCBI Official Synonym Symbols: | ILT3; LIR5; CD85K; ILT-3; LIR-5 |
NCBI Protein Information: | leukocyte immunoglobulin-like receptor subfamily B member 4; immunoglobulin-like transcript 3; CD85 antigen-like family member K; monocyte inhibitory receptor HM18; leukocyte immunoglobulin-like receptor 5 |
UniProt Protein Name: | Leukocyte immunoglobulin-like receptor subfamily B member 4 |
UniProt Synonym Protein Names: | CD85 antigen-like family member K; Immunoglobulin-like transcript 3; ILT-3; Leukocyte immunoglobulin-like receptor 5; LIR-5; Monocyte inhibitory receptor HM18; CD_antigen: CD85k |
Protein Family: | Leukocyte immunoglobulin-like receptor subfamily |
UniProt Gene Name: | LILRB4 |
UniProt Entry Name: | LIRB4_HUMAN |