LILRB3 Antibody (PACO18111)
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주문- SKU:
- PACO18111
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | LILRB3 Antibody (PACO18111) |
Antibody SKU: | PACO18111 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:15-1:50 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human LILRB3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO18111(LILRB3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 |
UniProt Protein Function: | Function: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM) |
UniProt Protein Details: | By similarity. Subunit structure: Interacts with LYN, PTPN6/SHP-1 and PTPN11/SHP-2 By similarity. Ref.5 Subcellular location: Cell membrane; Single-pass type I membrane protein. Tissue specificity: Detected in monocytes and B-cells. Ref.2 Domain: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, including PTPN6/SHP-1, resulting in the dephosphorylation of the downstream protein kinases SYK and BTK By similarity. Post-translational modification: Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2 By similarity. Miscellaneous: Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4. Sequence similarities: Contains 4 Ig-like C2-type (immunoglobulin-like) domains. |
NCBI Summary: | This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O75022 |
NCBI GenInfo Identifier: | 125661043 |
NCBI Gene ID: | 11025 |
NCBI Accession: | NP_001074919.1 |
UniProt Secondary Accession: | O75022,O15471, Q86U49, C9J1P3, C9JIP1, |
UniProt Related Accession: | O75022 |
Molecular Weight: | 69,386 Da |
NCBI Full Name: | leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 1 |
NCBI Synonym Full Names: | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 |
NCBI Official Symbol: | LILRB3 |
NCBI Official Synonym Symbols: | HL9; ILT5; LIR3; PIRB; CD85A; ILT-5; LIR-3; LILRA6 |
NCBI Protein Information: | leukocyte immunoglobulin-like receptor subfamily B member 3; immunoglobulin-like transcript 5; monocyte inhibitory receptor HL9; CD85 antigen-like family member A; leukocyte immunoglobulin-like receptor 3; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 |
UniProt Protein Name: | Leukocyte immunoglobulin-like receptor subfamily B member 3 |
UniProt Synonym Protein Names: | CD85 antigen-like family member A; Immunoglobulin-like transcript 5; ILT-5; Monocyte inhibitory receptor HL9 |
UniProt Gene Name: | LILRB3 |
UniProt Entry Name: | LIRB3_HUMAN |
Antibodies |
Anti-LILRB3 Antibody (CAB16103) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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