LILRB1 Antibody (PACO14605)
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주문- SKU:
- PACO14605
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | LILRB1 Antibody (PACO14605) |
Antibody SKU: | PACO14605 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human LILRB1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO14605(LILRB1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO14605(LILRB1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 |
UniProt Protein Function: | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. |
NCBI Summary: | This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8NHL6 |
NCBI GenInfo Identifier: | 37537910 |
NCBI Gene ID: | 10859 |
NCBI Accession: | Q8NHL6.1 |
UniProt Secondary Accession: | Q8NHL6,O75024, O75025, Q8NHJ9, Q8NHK0, A2IXV4, A8MXT0 |
UniProt Related Accession: | Q8NHL6 |
Molecular Weight: | 49,356 Da |
NCBI Full Name: | Leukocyte immunoglobulin-like receptor subfamily B member 1 |
NCBI Synonym Full Names: | leukocyte immunoglobulin like receptor B1 |
NCBI Official Symbol: | LILRB1 |
NCBI Official Synonym Symbols: | ILT2; LIR1; MIR7; PIRB; CD85J; ILT-2; LIR-1; MIR-7; PIR-B |
NCBI Protein Information: | leukocyte immunoglobulin-like receptor subfamily B member 1 |
UniProt Protein Name: | Leukocyte immunoglobulin-like receptor subfamily B member 1 |
UniProt Synonym Protein Names: | CD85 antigen-like family member J; Immunoglobulin-like transcript 2; ILT-2; Monocyte/macrophage immunoglobulin-like receptor 7; MIR-7; CD_antigen: CD85j |
Protein Family: | Leukocyte immunoglobulin-like receptor subfamily |
UniProt Gene Name: | LILRB1 |
UniProt Entry Name: | LIRB1_HUMAN |
Antibodies | ELISA Kits |
Anti-LILRB1 Antibody (CAB12827) | Human LILRB1 / CD85j / ILT2 ELISA Kit |
LILRB1 Antibody (PACO02252) | Human Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |