LGI1 Antibody (PACO43882)
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주문- SKU:
- PACO43882
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | LGI1 Antibody (PACO43882) |
Antibody SKU: | PACO43882 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Leucine-rich glioma-inactivated protein 1 protein (35-285AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43882 at dilution of 1: 100. |
Background: | Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. |
Synonyms: | Leucine-rich glioma-inactivated protein 1 (Epitempin-1), LGI1, EPT |
UniProt Protein Function: | LGI1: Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. Defects in LGI1 are the cause of epilepsy, familial temporal lobe, type 1 (ETL1). A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 10q24 Cellular Component: extracellular space; extracellular region; synapse; cell junction Molecular Function:protein binding; receptor binding Biological Process: axon guidance; nervous system development; cell proliferation; positive regulation of cell growth; neurite development; protein homooligomerization; positive regulation of synaptic transmission Disease: Epilepsy, Familial Temporal Lobe, 1 |
NCBI Summary: | This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. [provided by RefSeq, Jul 2008] |
UniProt Code: | O95970 |
NCBI GenInfo Identifier: | 32469669 |
NCBI Gene ID: | 9211 |
NCBI Accession: | O95970.1 |
UniProt Secondary Accession: | O95970,Q5W001, Q5W002, Q8NI23, Q96LF5, A8K0Z1, B4E1S0 |
UniProt Related Accession: | O95970 |
Molecular Weight: | 557 |
NCBI Full Name: | Leucine-rich glioma-inactivated protein 1 |
NCBI Synonym Full Names: | leucine-rich, glioma inactivated 1 |
NCBI Official Symbol: | LGI1 |
NCBI Official Synonym Symbols: | EPT; ETL1; ADLTE; ADPAEF; ADPEAF; IB1099; EPITEMPIN |
NCBI Protein Information: | leucine-rich glioma-inactivated protein 1; epitempin-1 |
UniProt Protein Name: | Leucine-rich glioma-inactivated protein 1 |
UniProt Synonym Protein Names: | Epitempin-1 |
Protein Family: | Leucine-rich glioma-inactivated protein |
UniProt Gene Name: | LGI1 |
UniProt Entry Name: | LGI1_HUMAN |