LEPR Antibody (PACO48514)
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주문- SKU:
- PACO48514
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | LEPR Antibody (PACO48514) |
Antibody SKU: | PACO48514 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Leptin receptor protein (874-1075AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescent analysis of HepG2 cells using PACO48514 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity. Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity). |
Synonyms: | Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295), LEPR, DB OBR |
UniProt Protein Function: | LEPR: the receptor for leptin (obesity factor). A single-transmembrane-domain receptor of the cytokine receptor family. On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Five alternatively spliced transcript variants have been reported. |
UniProt Protein Details: | Protein type:Receptor, cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p31 Cellular Component: plasma membrane; extracellular region; integral to membrane; receptor complex Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; identical protein binding; protein binding; transmembrane receptor activity Biological Process: cholesterol metabolic process; cell surface receptor linked signal transduction; negative regulation of gluconeogenesis; multicellular organismal development; cytokine and chemokine mediated signaling pathway; negative regulation of hydrolase activity; energy reserve metabolic process Disease: Leptin Receptor Deficiency |
NCBI Summary: | The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010] |
UniProt Code: | P48357 |
NCBI GenInfo Identifier: | 116242617 |
NCBI Gene ID: | 3953 |
NCBI Accession: | P48357.2 |
UniProt Secondary Accession: | P48357,Q13592, Q13593, Q13594, Q92919, Q92920, Q92921 |
UniProt Related Accession: | P48357 |
Molecular Weight: | 96,042 Da |
NCBI Full Name: | Leptin receptor |
NCBI Synonym Full Names: | leptin receptor |
NCBI Official Symbol: | LEPR |
NCBI Official Synonym Symbols: | OBR; OB-R; CD295; LEP-R; LEPRD |
NCBI Protein Information: | leptin receptor; huB219; OB receptor |
UniProt Protein Name: | Leptin receptor |
UniProt Synonym Protein Names: | HuB219; OB receptor; OB-R; CD_antigen: CD295 |
Protein Family: | Leptin receptor |
UniProt Gene Name: | LEPR |
UniProt Entry Name: | LEPR_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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