LCP1 Antibody (PACO16627)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO16627
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | LCP1 Antibody (PACO16627) |
Antibody SKU: | PACO16627 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human LCP1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Raji cells, Primary antibody: PACO16627(LCP1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
Background: | Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). |
Synonyms: | lymphocyte cytosolic protein 1 |
UniProt Protein Function: | L-plastin: Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Monomer. Interacts with AIF1. Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T- lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 13q14.3 Cellular Component: actin cytoskeleton; actin filament; actin filament bundle; cytoplasm; cytosol; extracellular space; filopodium; focal adhesion; plasma membrane; podosome; ruffle; stress fiber Molecular Function:actin filament binding; GTPase binding Biological Process: actin filament bundle formation; cell migration; extracellular matrix disassembly; regulation of intracellular protein transport; T cell activation during immune response |
NCBI Summary: | Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008] |
UniProt Code: | P13796 |
NCBI GenInfo Identifier: | 308153685 |
NCBI Gene ID: | 3936 |
NCBI Accession: | P13796.6 |
UniProt Secondary Accession: | P13796,Q5TBN4, B2R613, B4DUA0, |
UniProt Related Accession: | P13796 |
Molecular Weight: | 21,792 Da |
NCBI Full Name: | Plastin-2 |
NCBI Synonym Full Names: | lymphocyte cytosolic protein 1 |
NCBI Official Symbol: | LCP1 |
NCBI Official Synonym Symbols: | LPL; CP64; PLS2; LC64P; HEL-S-37; L-PLASTIN |
NCBI Protein Information: | plastin-2 |
UniProt Protein Name: | Plastin-2 |
UniProt Synonym Protein Names: | L-plastin; LC64P; Lymphocyte cytosolic protein 1; LCP-1 |
Protein Family: | Larval cuticle protein |
UniProt Gene Name: | LCP1 |
UniProt Entry Name: | PLSL_HUMAN |