LAX1 Antibody (PACO50766)
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주문- SKU:
- PACO50766
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | LAX1 Antibody (PACO50766) |
Antibody SKU: | PACO50766 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Recombinant Human Lymphocyte transmembrane adapter 1 protein (107-298AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, NIH/3T3 whole cell lysate, MCF-7 whole cell lysate, Mouse brain tissue, Rat heart tissue. All lanes: LAX1 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 45, 36, 43 kDa. Observed band size: 51, 45, 36 kDa.. | |
Immunofluorescent analysis of HepG2 cells using PACO50766 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. |
Synonyms: | Lymphocyte transmembrane adapter 1 (Linker for activation of X cells) (Membrane-associated adapter protein LAX), LAX1, LAX |
UniProt Protein Function: | LAX1: Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: cytosol; Golgi apparatus; integral to membrane; lipid raft; membrane; plasma membrane Molecular Function:protein binding; protein kinase binding; SH2 domain binding Biological Process: B cell activation; immune response; inactivation of MAPK activity; negative regulation of T cell activation |
UniProt Code: | Q8IWV1 |
NCBI GenInfo Identifier: | 74728197 |
NCBI Gene ID: | 54900 |
NCBI Accession: | Q8IWV1.1 |
UniProt Secondary Accession: | Q8IWV1,Q6NSZ6, Q9NXB4, B7Z744, J3KP69, |
UniProt Related Accession: | Q8IWV1 |
Molecular Weight: | 44kDa |
NCBI Full Name: | Lymphocyte transmembrane adapter 1 |
NCBI Synonym Full Names: | lymphocyte transmembrane adaptor 1 |
NCBI Official Symbol: | LAX1 |
NCBI Official Synonym Symbols: | LAX |
NCBI Protein Information: | lymphocyte transmembrane adapter 1 |
UniProt Protein Name: | Lymphocyte transmembrane adapter 1 |
UniProt Synonym Protein Names: | Linker for activation of X cells; Membrane-associated adapter protein LAX |
Protein Family: | Lymphocyte transmembrane adapter |
UniProt Gene Name: | LAX1 |