UniProt Protein Function: | Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8+ T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. |
NCBI Summary: | This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010] |
UniProt Code: | P26718 |
NCBI GenInfo Identifier: | 128370 |
NCBI Gene ID: | 100528032 |
NCBI Accession: | P26718.1 |
UniProt Secondary Accession: | P26718,Q9NR41, A8K7K5, A8K7P4, |
UniProt Related Accession: | P26718 |
Molecular Weight: | 25,274 Da |
NCBI Full Name: | NKG2-D type II integral membrane protein |
NCBI Synonym Full Names: | KLRC4-KLRK1 readthrough |
NCBI Official Symbol: | KLRC4-KLRK1 |
NCBI Protein Information: | NKG2-D type II integral membrane protein |
UniProt Protein Name: | NKG2-D type II integral membrane protein |
UniProt Synonym Protein Names: | Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CD_antigen: CD314 |
Protein Family: | NKG2-D type II integral membrane protein |
UniProt Gene Name: | KLRK1 |