KIR2DS4 Antibody (PACO10113)
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주문- SKU:
- PACO10113
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | KIR2DS4 Antibody (PACO10113) |
Antibody SKU: | PACO10113 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | |
Species Reactivity: | Human |
Immunogen: | Human KIR2DS4 |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4;KIR2DS4;CD158I;KIR1D;KIR412;KKA3;MGC120019;MGC125315;MGC125317;NKAT8 ; |
UniProt Protein Function: | KIR2DS4: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Belongs to the immunoglobulin superfamily. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: integral to plasma membrane; plasma membrane Biological Process: innate immune response |
NCBI Summary: | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] |
UniProt Code: | P43632 |
NCBI GenInfo Identifier: | 2828511 |
NCBI Gene ID: | 3809 |
NCBI Accession: | P43632.2 |
UniProt Secondary Accession: | P43632,Q6H2G7, |
UniProt Related Accession: | P43632 |
Molecular Weight: | 304 |
NCBI Full Name: | Killer cell immunoglobulin-like receptor 2DS4 |
NCBI Synonym Full Names: | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 |
NCBI Official Symbol: | KIR2DS4 |
NCBI Official Synonym Symbols: | KKA3; KIR1D; NKAT8; CD158I; KIR412; NKAT-8; KIR2DS1 |
NCBI Protein Information: | killer cell immunoglobulin-like receptor 2DS4; KIR antigen 2DS4; killer Ig receptor; p58 NK receptor CL-39/CL-17; MHC class I NK cell receptor; killer inhibitory receptor 4-1-2; CD158 antigen-like family member I; natural killer-associated transcript 8; natural killer cell inhibitory receptor; P58 natural killer cell receptor clones CL-39/CL-17; killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 1 |
UniProt Protein Name: | Killer cell immunoglobulin-like receptor 2DS4 |
UniProt Synonym Protein Names: | CD158 antigen-like family member I; MHC class I NK cell receptor; Natural killer-associated transcript 8; NKAT-8; P58 natural killer cell receptor clones CL-39/CL-17; p58 NK receptor CL-39/CL-17; CD_antigen: CD158i |
Protein Family: | Killer cell immunoglobulin-like receptor |
UniProt Gene Name: | KIR2DS4 |
UniProt Entry Name: | KI2S4_HUMAN |