KDM4B Antibody (PACO20189)
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주문- SKU:
- PACO20189
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | KDM4B Antibody (PACO20189) |
Antibody SKU: | PACO20189 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human KDM4B |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO20189(KDM4B Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO20189(KDM4B Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | JMJD2B (JmjC domain-containing histone demethylation protein 3A) is a 1,064 amino acid, protein encoded by the human gene JMJD2B. JMJD2B belongs to the JMJD2B histone demethylase family and contains one JmjC domain, one JmjN domain, two PHD-type zinc fingers and two Tudor domains. The two Tudor domains recognize and bind methylated histones and have an interdigitated structure; the unusual fold is required for its ability to bind methylated histone tails. JMJD2B is a histone demethylase that specifically demethylates Lys 9 residues of Histone H3, thereby playing a role in histone code. It does not demethylate Histone H3 Lys 4, H3 Lys 27, H3 Lys 36 or H4 Lys 20, however, and is only able to demethylate trimethylated H3 Lys-9 and has weaker activity than JMJD2A, JMJD2C and JMJD2D. JMJD2B demethyl-ation of Lysine residues will generate formaldehyde and succinate. JMJD2B is a ubiquitously expressed nuclear protein. |
Synonyms: | lysine (K)-specific demethylase 4B |
UniProt Protein Function: | JMJD2B: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Belongs to the JHDM3 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 1.14.11.-; Oxidoreductase; Demethylase Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:histone demethylase activity |
UniProt Code: | O94953 |
NCBI GenInfo Identifier: | 134047803 |
NCBI Gene ID: | 23030 |
NCBI Accession: | O94953.4 |
UniProt Secondary Accession: | O94953,O75274, Q6P3R5, Q9P1V1, Q9UF40, B9EGN8, D6W631 |
UniProt Related Accession: | O94953 |
Molecular Weight: | 50,582 Da |
NCBI Full Name: | Lysine-specific demethylase 4B |
NCBI Synonym Full Names: | lysine demethylase 4B |
NCBI Official Symbol: | KDM4B |
NCBI Official Synonym Symbols: | JMJD2B; TDRD14B |
NCBI Protein Information: | lysine-specific demethylase 4B |
UniProt Protein Name: | Lysine-specific demethylase 4B |
UniProt Synonym Protein Names: | JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B |
Protein Family: | Lysine-specific demethylase |
UniProt Gene Name: | KDM4B |
UniProt Entry Name: | KDM4B_HUMAN |