KDM1A Antibody (PACO21087)
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주문- SKU:
- PACO21087
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | KDM1A Antibody (PACO21087) |
Antibody SKU: | PACO21087 |
Size: | 100ul(100ug) |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Recombinant protein of human KDM1A |
Form: | Liquid |
Storage Buffer: | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of SW480 cell and PC-3 cell lysate using KDM1A antibody. |
Background: | Lysine-specific demethylase 1 (LSD1; also known as AOF2 and BHC110) is a nuclear amine oxidase homolog that acts as a histone demethylase and transcription cofactor. Gene activation and repression is specifically regulated by the methylation state of distinct histone protein lysine residues. For example, methylation of histone H3 at Lys4 facilitates transcriptional activation by coordinating the recruitment of BPTF, a component of the NURF chromatin remodeling complex, and WDR5, a component of multiple histone methyltransferase complexes. In contrast, methylation of histone H3 at Lys9 facilitates transcriptional repression by recruiting HP1. LSD1 is a component of the CoREST transcriptional co-repressor complex that also contains CoREST, CtBP, HDAC1 and HDAC2. As part of this complex, LSD1 demethylates mono-methyl and di-methyl histone H3 at Lys4 through a FAD-dependent oxidation reaction to facilitate neuronal-specific gene repression in non-neuronal cells. In contrast, LSD1 associates with androgen receptor in human prostate cells to demethylate mono-methyl and di-methyl histone H3 at Lys9 and facilitate androgen receptor-dependent transcriptional activation. Therefore, depending on gene context LSD1 can function as either a transcriptional co-repressor or co-activator. LSD1 activity is inhibited by the amine oxidase inhibitors pargyline, deprenyl, clorgyline and tranylcypromine. |
Synonyms: | KDM1;AOF2;BHC110;KIAA0601;LSD1 ;KDM1A |
UniProt Code: | O60341 |
NCBI GenInfo Identifier: | 58761544 |
NCBI Gene ID: | 23028 |
NCBI Accession: | NP_001009999.1 |
UniProt Secondary Accession: | O60341,Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3 Q96AW4, A8MWP9, |
UniProt Related Accession: | O60341 |
Molecular Weight: | 852 |
NCBI Full Name: | lysine-specific histone demethylase 1A isoform a |
NCBI Synonym Full Names: | lysine (K)-specific demethylase 1A |
NCBI Official Symbol: | KDM1A |
NCBI Official Synonym Symbols: | AOF2; KDM1; LSD1; BHC110 |
NCBI Protein Information: | lysine-specific histone demethylase 1A; lysine (K)-specific demethylase 1; BRAF35-HDAC complex protein BHC110; amine oxidase (flavin containing) domain 2; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; flavin-containing amine oxidase domain-con |
UniProt Protein Name: | Lysine-specific histone demethylase 1A |
UniProt Synonym Protein Names: | BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2 |
Protein Family: | Lysine-specific histone demethylase |
UniProt Gene Name: | KDM1A |
UniProt Entry Name: | KDM1A_HUMAN |