KCNN4 Antibody (PACO19893)
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주문- SKU:
- PACO19893
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | KCNN4 Antibody (PACO19893) |
Antibody SKU: | PACO19893 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:100-1:300 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human KCNN4 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19893(KCNN4 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19893(KCNN4 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. |
Synonyms: | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 |
UniProt Protein Function: | KCNN4: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily. |
UniProt Protein Details: | Protein type:Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: apical plasma membrane; basolateral plasma membrane; cell soma; lipid raft; plasma membrane; voltage-gated potassium channel complex Molecular Function:calcium-activated potassium channel activity; calmodulin binding; Intermediate conductance calcium-activated potassium channel activity; protein binding; protein phosphatase binding; small conductance calcium-activated potassium channel activity Biological Process: calcium ion transport; cell volume homeostasis; defense response; immune system process; phospholipid translocation; positive regulation of protein secretion; positive regulation of T cell receptor signaling pathway; potassium ion transport; saliva secretion; stabilization of membrane potential; synaptic transmission |
NCBI Summary: | The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008] |
UniProt Code: | O15554 |
NCBI GenInfo Identifier: | 17366160 |
NCBI Gene ID: | 3783 |
NCBI Accession: | O15554.1 |
UniProt Secondary Accession: | O15554,Q53XR4, |
UniProt Related Accession: | O15554 |
Molecular Weight: | 47,696 Da |
NCBI Full Name: | Intermediate conductance calcium-activated potassium channel protein 4 |
NCBI Synonym Full Names: | potassium calcium-activated channel subfamily N member 4 |
NCBI Official Symbol: | KCNN4 |
NCBI Official Synonym Symbols: | IK; IK1; SK4; DHS2; KCA4; hSK4; IKCA1; hKCa4; KCa3.1; hIKCa1 |
NCBI Protein Information: | intermediate conductance calcium-activated potassium channel protein 4 |
UniProt Protein Name: | Intermediate conductance calcium-activated potassium channel protein 4 |
UniProt Synonym Protein Names: | IKCa1; IK1; KCa3.1; KCa4; Putative Gardos channel |
Protein Family: | Intermediate conductance calcium-activated potassium channel protein |
UniProt Gene Name: | KCNN4 |
UniProt Entry Name: | KCNN4_HUMAN |