KCNJ1 Antibody (PACO27749)
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주문- SKU:
- PACO27749
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | KCNJ1 Antibody (PACO27749) |
Antibody SKU: | PACO27749 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human ATP-sensitive inward rectifier potassium channel 1 protein (178-391AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: KCNJ1 antibody at 2µg/ml Lane 1: HepG2 whole cell lysate Lane 2: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 45, 43 kDa Observed band size: 45 kDa . | |
Immunofluorescent analysis of Hela cells using PACO27749 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Synonyms: | ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1), KCNJ1, ROMK1 |
UniProt Protein Function: | In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. |
NCBI Summary: | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P48048 |
NCBI GenInfo Identifier: | 1352479 |
NCBI Gene ID: | 3758 |
NCBI Accession: | P48048.1 |
UniProt Secondary Accession: | P48048,Q6LD67, B2RMR4, |
UniProt Related Accession: | P48048 |
Molecular Weight: | 44,611 Da |
NCBI Full Name: | ATP-sensitive inward rectifier potassium channel 1 |
NCBI Synonym Full Names: | potassium voltage-gated channel subfamily J member 1 |
NCBI Official Symbol: | KCNJ1 |
NCBI Official Synonym Symbols: | ROMK; ROMK1; KIR1.1 |
NCBI Protein Information: | ATP-sensitive inward rectifier potassium channel 1 |
UniProt Protein Name: | ATP-sensitive inward rectifier potassium channel 1 |
UniProt Synonym Protein Names: | ATP-regulated potassium channel ROM-K; Inward rectifier K(+) channel Kir1.1; Potassium channel, inwardly rectifying subfamily J member 1 |
Protein Family: | ATP-sensitive inward rectifier potassium channel |
UniProt Gene Name: | KCNJ1 |
UniProt Entry Name: | KCNJ1_HUMAN |
Antibodies |
Anti-KCNJ1 Antibody (CAB8554) |
Phospho-KCNJ1 (S44) Antibody (PACO05969) |
KCNJ1 Antibody (PACO05970) |
KCNJ1 Antibody (PACO10056) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |