JAK1 (Ab-1022) Antibody (PACO22911)
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주문- SKU:
- PACO22911
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | JAK1 (Ab-1022) Antibody (PACO22911) |
Antibody SKU: | PACO22911 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Peptide sequence around aa. 1020~1024 (K-E-Y-Y-T) derived from Human JAK1. |
Form: | Liquid |
Storage Buffer: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from 3T3, HepG2, HT29 and MDA cells using JAK1(Ab-1022) Antibody. | |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using JAK1(Ab-1022) Antibody(left) or the same antibody preincubated with blocking peptide(right). |
Background: | Tyrosine kinase of the non-receptor type, involved in the IFN-a/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. |
Synonyms: | Janus kinase 1 |
UniProt Protein Function: | JAK1: a widely expressed non-receptor tyrosine-kinase involved in the interferon-alpha/beta and -gamma signal transduction pathways. Couples cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. A selective Jak1 inhibitor induces apoptosis in NRP-154 prostate cancer cell line. A single mutation seen in tyrosine kinome screen of colon cancers. Activated in B cell lines from patients with post-transplant lymphoproliferative disorder, and in a mouse Lck-driven T cell lymphoma. Inhibitor: Piceatannol. |
UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.10.2; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; JakA family Chromosomal Location of Human Ortholog: 1p32.3-p31.3 Cellular Component: cytoplasm; cytoskeleton; cytosol; endomembrane system; extrinsic to internal side of plasma membrane; focal adhesion; nucleus Molecular Function:ATP binding; CCR5 chemokine receptor binding; growth hormone receptor binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein phosphatase binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding; ubiquitin protein ligase binding Biological Process: cell differentiation; cell migration; innate immune response; MAPKKK cascade; positive regulation of GTPase activity; protein amino acid phosphorylation; regulation of cell proliferation; response to antibiotic; transmembrane receptor protein tyrosine kinase signaling pathway |
NCBI Summary: | This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
UniProt Code: | P23458 |
NCBI GenInfo Identifier: | 215274013 |
NCBI Gene ID: | 3716 |
NCBI Accession: | P23458.2 |
UniProt Secondary Accession: | P23458,Q59GQ2, Q9UD26, |
UniProt Related Accession: | P23458 |
Molecular Weight: | |
NCBI Full Name: | Tyrosine-protein kinase JAK1 |
NCBI Synonym Full Names: | Janus kinase 1 |
NCBI Official Symbol: | JAK1 |
NCBI Official Synonym Symbols: | JTK3; JAK1A; JAK1B |
NCBI Protein Information: | tyrosine-protein kinase JAK1 |
UniProt Protein Name: | Tyrosine-protein kinase JAK1 |
UniProt Synonym Protein Names: | Janus kinase 1; JAK-1 |
Protein Family: | Tyrosine-protein kinase |
UniProt Gene Name: | JAK1 |
UniProt Entry Name: | JAK1_HUMAN |
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