IRF9 Antibody (PACO14598)
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주문- SKU:
- PACO14598
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IRF9 Antibody (PACO14598) |
Antibody SKU: | PACO14598 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human IRF9 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO14598(IRF9 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse panceas tissue, NIH/3T3 cells, Primary antibody: PACO14598(IRF9 Antibody) at dilution 1/380, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1.5 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO14598(IRF9 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G. Transcription regulatory factor that mediates signaling by type I IFNs (IFN-α and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. |
Synonyms: | interferon regulatory factor 9 |
UniProt Protein Function: | IRF9: Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Belongs to the IRF family. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus Molecular Function:protein binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; cell surface receptor linked signal transduction; regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; interferon type I biosynthetic process; defense response to virus |
UniProt Code: | Q00978 |
NCBI GenInfo Identifier: | 266392 |
NCBI Gene ID: | 10379 |
NCBI Accession: | Q00978.1 |
UniProt Secondary Accession: | Q00978,D3DS61, |
UniProt Related Accession: | Q00978 |
Molecular Weight: | 393 |
NCBI Full Name: | Interferon regulatory factor 9 |
NCBI Synonym Full Names: | interferon regulatory factor 9 |
NCBI Official Symbol: | IRF9 |
NCBI Official Synonym Symbols: | p48; IRF-9; ISGF3; ISGF3G |
NCBI Protein Information: | interferon regulatory factor 9; ISGF-3 gamma; ISGF3 p48 subunit; interferon-stimulated gene factor 3 gamma; transcriptional regulator ISGF3 subunit gamma; IFN-alpha-responsive transcription factor subunit; interferon-stimulated transcription factor 3, gamma 48kDa |
UniProt Protein Name: | Interferon regulatory factor 9 |
UniProt Synonym Protein Names: | IFN-alpha-responsive transcription factor subunit; ISGF3 p48 subunit; Interferon-stimulated gene factor 3 gamma; ISGF-3 gamma; Transcriptional regulator ISGF3 subunit gamma |
Protein Family: | Interferon regulatory factor |
UniProt Gene Name: | IRF9 |
UniProt Entry Name: | IRF9_HUMAN |
Antibodies |
Anti-IRF9 Antibody (CAB1004) |
Anti-IRF9 Antibody (CAB18008)[KO Validated] |
IRF9 Antibody (PACO09993) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |