UniProt Protein Function: | IRF4: Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Interacts with SPIB and DEF6. Not induced by interferons. Lymphoid cells. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor; Oncoprotein Chromosomal Location of Human Ortholog: 6p25-p23 Cellular Component: nucleoplasm; membrane; cytoplasm; cytosol; nucleus Molecular Function:protein binding; sequence-specific DNA binding; protein-lysine N-methyltransferase activity; transcription factor binding; transcription factor activity Biological Process: transcription, DNA-dependent; T cell activation; cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-2 biosynthetic process; positive regulation of transcription, DNA-dependent; regulation of T-helper cell differentiation; myeloid dendritic cell differentiation; defense response to protozoan; peptidyl-lysine methylation; positive regulation of interleukin-10 biosynthetic process; positive regulation of interleukin-4 biosynthetic process; positive regulation of interleukin-13 biosynthetic process; negative regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA binding Disease: Skin/hair/eye Pigmentation, Variation In, 8 |
NCBI Summary: | The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010] |
UniProt Code: | Q15306 |
NCBI GenInfo Identifier: | 2497445 |
NCBI Gene ID: | 3662 |
NCBI Accession: | Q15306.1 |
UniProt Secondary Accession: | Q15306,Q5VUI7, Q99660, |
UniProt Related Accession: | Q15306 |
Molecular Weight: | 451 |
NCBI Full Name: | Interferon regulatory factor 4 |
NCBI Synonym Full Names: | interferon regulatory factor 4 |
NCBI Official Symbol: | IRF4 |
NCBI Official Synonym Symbols: | MUM1; LSIRF; SHEP8; NF-EM5 |
NCBI Protein Information: | interferon regulatory factor 4; multiple myeloma oncogene 1; lymphocyte-specific interferon regulatory factor |
UniProt Protein Name: | Interferon regulatory factor 4 |
UniProt Synonym Protein Names: | Lymphocyte-specific interferon regulatory factor; LSIRF; Multiple myeloma oncogene 1; NF-EM5 |
Protein Family: | Interferon regulatory factor |
UniProt Gene Name: | IRF4 |
UniProt Entry Name: | IRF4_HUMAN |