UniProt Protein Function: | INTS11: Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:RNA processing; Ribonuclease; EC 3.1.27.- Chromosomal Location of Human Ortholog: 1p36.33 Cellular Component: cytoplasm; integrator complex Molecular Function:protein binding; hydrolase activity Biological Process: snRNA processing |
NCBI Summary: | The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q5TA45 |
NCBI GenInfo Identifier: | 118572557 |
NCBI Gene ID: | 54973 |
NCBI Accession: | Q5TA45.2 |
UniProt Secondary Accession: | Q5TA45,Q5TA46, Q5TA48, Q5TA52, Q5TA53, Q5TA54, Q7L3D7 Q96HY1, A8K5S2, B3KPR3, B4DM87, G3V1S5, |
UniProt Related Accession: | Q5TA45 |
Molecular Weight: | 600 |
NCBI Full Name: | Integrator complex subunit 11 |
NCBI Synonym Full Names: | cleavage and polyadenylation specific factor 3-like |
NCBI Official Symbol: | CPSF3L |
NCBI Official Synonym Symbols: | RC68; INT11; RC-68; INTS11; CPSF73L |
NCBI Protein Information: | integrator complex subunit 11; CPSF3-like protein; related to CPSF subunits 68 kDa; protein related to CPSF subunits of 68 kDa; cleavage and polyadenylation-specific factor 3-like protein |
UniProt Protein Name: | Integrator complex subunit 11 |
UniProt Synonym Protein Names: | Cleavage and polyadenylation-specific factor 3-like protein; CPSF3-like protein; Protein related to CPSF subunits of 68 kDa; RC-68 |
UniProt Gene Name: | CPSF3L |
UniProt Entry Name: | INT11_HUMAN |