ILKAP Antibody (PACO27637)
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주문- SKU:
- PACO27637
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ILKAP Antibody (PACO27637) |
Antibody SKU: | PACO27637 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Recombinant Human Integrin-linked kinase-associated serine/threonine phosphatase 2C protein (1-392AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: ILKAP antibody at 2µg/ml Lane 1: Rat kidney tissue Lane 2: U251 whole cell lysate Lane 3: Mouse stomach tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 43 kDa Observed band size: 43 kDa . |
Background: | Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation |
Synonyms: | Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) (EC 3.1.3.16), ILKAP |
UniProt Protein Function: | ILKAP: a protein serine/threonine phosphatase of the PP2C family. Can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. Alternatively spliced transcript variants encoding distinct isoforms have been described. |
UniProt Protein Details: | Protein type:EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q37.3 Molecular Function:protein binding |
NCBI Summary: | The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9H0C8 |
NCBI GenInfo Identifier: | 74752560 |
NCBI Gene ID: | 80895 |
NCBI Accession: | Q9H0C8.1 |
UniProt Secondary Accession: | Q9H0C8,B3KM39, |
UniProt Related Accession: | Q9H0C8 |
Molecular Weight: | 42,907 Da |
NCBI Full Name: | Integrin-linked kinase-associated serine/threonine phosphatase 2C |
NCBI Synonym Full Names: | ILK associated serine/threonine phosphatase |
NCBI Official Symbol: | ILKAP |
NCBI Official Synonym Symbols: | PPM1O; ILKAP2; ILKAP3; PP2C-DELTA |
NCBI Protein Information: | integrin-linked kinase-associated serine/threonine phosphatase 2C |
UniProt Protein Name: | Integrin-linked kinase-associated serine/threonine phosphatase 2C |
Protein Family: | Integrin-linked kinase-associated serine/threonine phosphatase |
UniProt Gene Name: | ILKAP |
UniProt Entry Name: | ILKAP_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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