IL6R Antibody (PACO02212)
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주문- SKU:
- PACO02212
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IL6R Antibody |
Antibody SKU: | PACO02212 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human |
Immunogen: | synthesized peptide derived from the Internal region of human IL-6Ralpha. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | IL6R; Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80; gp80; CD126 |
UniProt Protein Function: | Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. |
NCBI Summary: | This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011] |
UniProt Code: | P08887 |
NCBI GenInfo Identifier: | 124343 |
NCBI Gene ID: | 3570 |
NCBI Accession: | P08887.1 |
UniProt Secondary Accession: | P08887,Q16202, Q53EQ7, Q5FWG2, Q5VZ23, A8KAE8, B2R6V4 |
UniProt Related Accession: | P08887 |
Molecular Weight: | 40,237 Da |
NCBI Full Name: | Interleukin-6 receptor subunit alpha |
NCBI Synonym Full Names: | interleukin 6 receptor |
NCBI Official Symbol: | IL6R |
NCBI Official Synonym Symbols: | IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1 |
NCBI Protein Information: | interleukin-6 receptor subunit alpha |
UniProt Protein Name: | Interleukin-6 receptor subunit alpha |
UniProt Synonym Protein Names: | IL-6R 1; Membrane glycoprotein 80; gp80; CD_antigen: CD126 |
Protein Family: | Interleukin-6 receptor |
UniProt Gene Name: | IL6R |