IL2RA Antibody (PACO18098)
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주문- SKU:
- PACO18098
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IL2RA Antibody (PACO18098) |
Antibody SKU: | PACO18098 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human IL2RA |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 10+12%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: PACO18098(IL2RA Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second. |
Background: | The interleukin 2 (IL2) receptor α (IL2RA) and β (IL2RB) chains, together with the common γ chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric α chains (IL2RA) result in low-affinity receptor, while homodimeric β (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor α deficiency. |
Synonyms: | interleukin 2 receptor, alpha |
UniProt Protein Function: | IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 10p15.1 Cellular Component: plasma membrane Molecular Function:interleukin-2 binding; Ras guanyl-nucleotide exchange factor activity Biological Process: apoptosis; cell proliferation; cell surface receptor linked signal transduction; immune response; inflammatory response; MAPKKK cascade; regulation of T cell tolerance induction Disease: Diabetes Mellitus, Insulin-dependent, 10; Interleukin 2 Receptor, Alpha, Deficiency Of |
NCBI Summary: | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009] |
UniProt Code: | P01589 |
NCBI GenInfo Identifier: | 124317 |
NCBI Gene ID: | 3559 |
NCBI Accession: | P01589.1 |
UniProt Secondary Accession: | P01589,Q5W007, |
UniProt Related Accession: | P01589 |
Molecular Weight: | 30,819 Da |
NCBI Full Name: | Interleukin-2 receptor subunit alpha |
NCBI Synonym Full Names: | interleukin 2 receptor subunit alpha |
NCBI Official Symbol: | IL2RA |
NCBI Official Synonym Symbols: | p55; CD25; IL2R; IMD41; TCGFR; IDDM10 |
NCBI Protein Information: | interleukin-2 receptor subunit alpha |
UniProt Protein Name: | Interleukin-2 receptor subunit alpha |
UniProt Synonym Protein Names: | TAC antigen; p55; CD_antigen: CD25 |
UniProt Gene Name: | IL2RA |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |